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Target
Fructose-bisphosphate aldolase
Ligand
BDBM66330
Substrate
n/a
IC50
2387±n/a nM
Citation
 PubChem, PC Fluorescence-based biochemical high throughput dose response assay for inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosis PubChem Bioassay (2013)[AID] 
Target
Name:
Fructose-bisphosphate aldolase
Synonyms:
ALF_MYCTU | FBP aldolase | FBPA | Fructose-1,6-bisphosphate aldolase | Fructose-1,6-bisphosphate aldolase (FBA) | Fructose-bisphosphate aldolase | Probable fructose-bisphosphate aldolase Fba | fba
Type:
Protein
Mol. Mass.:
36539.01
Organism:
Mycobacterium tuberculosis (strain H37Rv)
Description:
P9WQA3
Residue:
344
Sequence:
MPIATPEVYAEMLGQAKQNSYAFPAINCTSSETVNAAIKGFADAGSDGIIQFSTGGAEFGSGLGVKDMVTGAVALAEFTHVIAAKYPVNVALHTDHCPKDKLDSYVRPLLAISAQRVSKGGNPLFQSHMWDGSAVPIDENLAIAQELLKAAAAAKIILEIEIGVVGGEEDGVANEINEKLYTSPEDFEKTIEALGAGEHGKYLLAATFGNVHGVYKPGNVKLRPDILAQGQQVAAAKLGLPADAKPFDFVFHGGSGSLKSEIEEALRYGVVKMNVDTDTQYAFTRPIAGHMFTNYDGVLKVDGEVGVKKVYDPRSYLKKAEASMSQRVVQACNDLHCAGKSLTH
  
Inhibitor
Name:
BDBM66330
Synonyms:
MLS000536978 | N-(1,3-diketoisoindolin-5-yl)tetrahydrofuran-2-carboxamide | N-(1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)tetrahydro-2-furancarboxamide | N-(1,3-dioxo-5-isoindolyl)-2-oxolanecarboxamide | N-(1,3-dioxoisoindol-5-yl)oxolane-2-carboxamide | N-[1,3-bis(oxidanylidene)isoindol-5-yl]oxolane-2-carboxamide | SMR000143615 | cid_2961183
Type:
Small organic molecule
Emp. Form.:
C13H12N2O4
Mol. Mass.:
260.2454
SMILES:
O=C(Nc1ccc2C(=O)NC(=O)c2c1)C1CCCO1
Structure:
Search PDB for entries with ligand similarity: