Reaction Details
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RecBCD enzyme subunit RecD
Ligand
BDBM96250
Substrate
n/a
IC50
>118458±n/a nM
Citation
PubChem, PC Absorbance-based bacterial cell-based high throughput dose response assay to identify inhibitors of RecBCD PubChem Bioassay (2013)[AID] More Info.:
Target
Name:
RecBCD enzyme subunit RecD
Synonyms:
RECD_ECOLI | exonuclease V (RecBCD complex), alpha chain | hopE | recD
Type:
Enzyme Catalytic Domain
Mol. Mass.:
66906.68
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130723
Residue:
608
Sequence:
MKLQKQLLEAVEHKQLRPLDVQFALTVAGDEHPAVTLAAALLSHDAGEGHVCLPLSRLENNEASHPLLATCVSEIGELQNWEECLLASQAVSRGDEPTPMILCGDRLYLNRMWCNERTVARFFNEVNHAIEVDEALLAQTLDKLFPVSDEINWQKVAAAVALTRRISVISGGPGTGKTTTVAKLLAALIQMADGERCRIRLAAPTGKAAARLTESLGKALRQLPLTDEQKKRIPEDASTLHRLLGAQPGSQRLRHHAGNPLHLDVLVVDEASMIDLPMMSRLIDALPDHARVIFLGDRDQLASVEAGAVLGDICAYANAGFTAERARQLSRLTGTHVPAGTGTEAASLRDSLCLLQKSYRFGSDSGIGQLAAAINRGDKTAVKTVFQQDFTDIEKRLLQSGEDYIAMLEEALAGYGRYLDLLQARAEPDLIIQAFNEYQLLCALREGPFGVAGLNERIEQFMQQKRKIHRHPHSRWYEGRPVMIARNDSALGLFNGDIGIALDRGQGTRVWFAMPDGNIKSVQPSRLPEHETTWAMTVHKSQGSEFDHAALILPSQRTPVVTRELVYTAVTRARRRLSLYADERILSAAIATRTERRSGLAALFSSRE
Inhibitor
Name:
BDBM96250
Synonyms:
(4,6-Dimethyl-1H-pyrazolo[3,4-b]pyridin-3-yl)-piperidin-1-yl-diazene | MLS000561665 | N-[(Z)-(4,6-dimethyl-3-pyrazolo[3,4-b]pyridinylidene)amino]-1-piperidinamine | N-[(Z)-(4,6-dimethylpyrazolo[3,4-b]pyridin-3-ylidene)amino]piperidin-1-amine | SMR000175407 | [(Z)-(4,6-dimethylpyrazolo[3,4-b]pyridin-3-ylidene)amino]-piperidino-amine | cid_9566735
Type:
Small organic molecule
Emp. Form.:
C13H18N6
Mol. Mass.:
258.3222
SMILES:
Cc1cc(C)c2c(N=NN3CCCCC3)[nH]nc2n1 |w:8.8|
Structure:
