Reaction Details Report a problem with these data
Target
RecBCD enzyme subunit RecD
Ligand
BDBM96251
Substrate
n/a
IC50
>118574±n/a nM
Citation
 PubChem, PC Absorbance-based bacterial cell-based high throughput dose response assay to identify inhibitors of RecBCD PubChem Bioassay (2013)[AID] 
Target
Name:
RecBCD enzyme subunit RecD
Synonyms:
RECD_ECOLI | exonuclease V (RecBCD complex), alpha chain | hopE | recD
Type:
Enzyme Catalytic Domain
Mol. Mass.:
66906.68
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130723
Residue:
608
Sequence:
MKLQKQLLEAVEHKQLRPLDVQFALTVAGDEHPAVTLAAALLSHDAGEGHVCLPLSRLENNEASHPLLATCVSEIGELQNWEECLLASQAVSRGDEPTPMILCGDRLYLNRMWCNERTVARFFNEVNHAIEVDEALLAQTLDKLFPVSDEINWQKVAAAVALTRRISVISGGPGTGKTTTVAKLLAALIQMADGERCRIRLAAPTGKAAARLTESLGKALRQLPLTDEQKKRIPEDASTLHRLLGAQPGSQRLRHHAGNPLHLDVLVVDEASMIDLPMMSRLIDALPDHARVIFLGDRDQLASVEAGAVLGDICAYANAGFTAERARQLSRLTGTHVPAGTGTEAASLRDSLCLLQKSYRFGSDSGIGQLAAAINRGDKTAVKTVFQQDFTDIEKRLLQSGEDYIAMLEEALAGYGRYLDLLQARAEPDLIIQAFNEYQLLCALREGPFGVAGLNERIEQFMQQKRKIHRHPHSRWYEGRPVMIARNDSALGLFNGDIGIALDRGQGTRVWFAMPDGNIKSVQPSRLPEHETTWAMTVHKSQGSEFDHAALILPSQRTPVVTRELVYTAVTRARRRLSLYADERILSAAIATRTERRSGLAALFSSRE
  
Inhibitor
Name:
BDBM96251
Synonyms:
6-methoxy-N'-[(Z)-(3-oxidanylidene-1-benzothiophen-2-ylidene)methyl]naphthalene-2-carbohydrazide | 6-methoxy-N'-[(Z)-(3-oxo-1-benzothiophen-2-ylidene)methyl]-2-naphthalenecarbohydrazide | 6-methoxy-N'-[(Z)-(3-oxo-1-benzothiophen-2-ylidene)methyl]naphthalene-2-carbohydrazide | MLS000585492 | N'-[(1E)-(3-hydroxy-1-benzothien-2-yl)methylene]-6-methoxy-2-naphthohydrazide | N'-[(Z)-(3-ketobenzothiophen-2-ylidene)methyl]-6-methoxy-naphthalene-2-carbohydrazide | SMR000207473 | cid_12005460
Type:
Small organic molecule
Emp. Form.:
C21H16N2O3S
Mol. Mass.:
376.428
SMILES:
COc1ccc2cc(ccc2c1)C(=O)NN=Cc1sc2ccccc2c1O |w:15.16|
Structure:
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