Reaction Details Report a problem with these data
Target
RecBCD enzyme subunit RecD
Ligand
BDBM64655
Substrate
n/a
IC50
43514±n/a nM
Citation
 PubChem, PC Absorbance-based bacterial cell-based high throughput dose response assay to identify inhibitors of RecBCD PubChem Bioassay (2013)[AID] 
Target
Name:
RecBCD enzyme subunit RecD
Synonyms:
RECD_ECOLI | exonuclease V (RecBCD complex), alpha chain | hopE | recD
Type:
Enzyme Catalytic Domain
Mol. Mass.:
66906.68
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130723
Residue:
608
Sequence:
MKLQKQLLEAVEHKQLRPLDVQFALTVAGDEHPAVTLAAALLSHDAGEGHVCLPLSRLENNEASHPLLATCVSEIGELQNWEECLLASQAVSRGDEPTPMILCGDRLYLNRMWCNERTVARFFNEVNHAIEVDEALLAQTLDKLFPVSDEINWQKVAAAVALTRRISVISGGPGTGKTTTVAKLLAALIQMADGERCRIRLAAPTGKAAARLTESLGKALRQLPLTDEQKKRIPEDASTLHRLLGAQPGSQRLRHHAGNPLHLDVLVVDEASMIDLPMMSRLIDALPDHARVIFLGDRDQLASVEAGAVLGDICAYANAGFTAERARQLSRLTGTHVPAGTGTEAASLRDSLCLLQKSYRFGSDSGIGQLAAAINRGDKTAVKTVFQQDFTDIEKRLLQSGEDYIAMLEEALAGYGRYLDLLQARAEPDLIIQAFNEYQLLCALREGPFGVAGLNERIEQFMQQKRKIHRHPHSRWYEGRPVMIARNDSALGLFNGDIGIALDRGQGTRVWFAMPDGNIKSVQPSRLPEHETTWAMTVHKSQGSEFDHAALILPSQRTPVVTRELVYTAVTRARRRLSLYADERILSAAIATRTERRSGLAALFSSRE
  
Inhibitor
Name:
BDBM64655
Synonyms:
1-(3,4-dichlorophenyl)-3-(pyridin-2-ylcarbonylamino)thiourea | 1-(3,4-dichlorophenyl)-3-(pyridine-2-carbonylamino)thiourea | 1-(3,4-dichlorophenyl)-3-[[oxo(2-pyridinyl)methyl]amino]thiourea | 1-(3,4-dichlorophenyl)-3-picolinamido-thiourea | MLS000662162 | N-(3,4-dichlorophenyl)-2-(2-pyridinylcarbonyl)hydrazinecarbothioamide | SMR000294066 | cid_969982
Type:
Small organic molecule
Emp. Form.:
C13H10Cl2N4OS
Mol. Mass.:
341.216
SMILES:
Clc1ccc(NC(=S)NNC(=O)c2ccccn2)cc1Cl
Structure:
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