Reaction Details Report a problem with these data
Target
RecBCD enzyme subunit RecD
Ligand
BDBM96266
Substrate
n/a
IC50
69866±n/a nM
Citation
 PubChem, PC Absorbance-based bacterial cell-based high throughput dose response assay to identify inhibitors of RecBCD PubChem Bioassay (2013)[AID] 
Target
Name:
RecBCD enzyme subunit RecD
Synonyms:
RECD_ECOLI | exonuclease V (RecBCD complex), alpha chain | hopE | recD
Type:
Enzyme Catalytic Domain
Mol. Mass.:
66906.68
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130723
Residue:
608
Sequence:
MKLQKQLLEAVEHKQLRPLDVQFALTVAGDEHPAVTLAAALLSHDAGEGHVCLPLSRLENNEASHPLLATCVSEIGELQNWEECLLASQAVSRGDEPTPMILCGDRLYLNRMWCNERTVARFFNEVNHAIEVDEALLAQTLDKLFPVSDEINWQKVAAAVALTRRISVISGGPGTGKTTTVAKLLAALIQMADGERCRIRLAAPTGKAAARLTESLGKALRQLPLTDEQKKRIPEDASTLHRLLGAQPGSQRLRHHAGNPLHLDVLVVDEASMIDLPMMSRLIDALPDHARVIFLGDRDQLASVEAGAVLGDICAYANAGFTAERARQLSRLTGTHVPAGTGTEAASLRDSLCLLQKSYRFGSDSGIGQLAAAINRGDKTAVKTVFQQDFTDIEKRLLQSGEDYIAMLEEALAGYGRYLDLLQARAEPDLIIQAFNEYQLLCALREGPFGVAGLNERIEQFMQQKRKIHRHPHSRWYEGRPVMIARNDSALGLFNGDIGIALDRGQGTRVWFAMPDGNIKSVQPSRLPEHETTWAMTVHKSQGSEFDHAALILPSQRTPVVTRELVYTAVTRARRRLSLYADERILSAAIATRTERRSGLAALFSSRE
  
Inhibitor
Name:
BDBM96266
Synonyms:
MLS001204199 | N-[(4-Chloro-phenyl)-(8-hydroxy-quinolin-7-yl)-methyl]-acetamide | N-[(4-chlorophenyl)-(8-hydroxy-7-quinolinyl)methyl]acetamide | N-[(4-chlorophenyl)-(8-hydroxy-7-quinolyl)methyl]acetamide | N-[(4-chlorophenyl)-(8-hydroxyquinolin-7-yl)methyl]acetamide | N-[(4-chlorophenyl)-(8-oxidanylquinolin-7-yl)methyl]ethanamide | SMR000516878 | cid_2871851
Type:
Small organic molecule
Emp. Form.:
C18H15ClN2O2
Mol. Mass.:
326.777
SMILES:
CC(=O)NC(c1ccc(Cl)cc1)c1ccc2cccnc2c1O
Structure:
Search PDB for entries with ligand similarity: