Reaction Details Report a problem with these data
Target
Galanin receptor type 3
Ligand
BDBM89400
Substrate
n/a
IC50
447.54±n/a nM
Citation
 PubChem, PC Fluorescence-based cell-based primary high throughput dose response assay to identify antagonists of the Galanin Receptor 3 (GalR3). PubChem Bioassay (2013)[AID] 
Target
Name:
Galanin receptor type 3
Synonyms:
GALNR3 | GALR3 | GALR3_HUMAN | Galanin R3 | Galanin receptor 3 | Galanin receptor type 3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
39599.97
Organism:
Homo sapiens (Human)
Description:
Galanin R3 GALR3 HUMAN::O60755
Residue:
368
Sequence:
MADAQNISLDSPGSVGAVAVPVVFALIFLLGTVGNGLVLAVLLQPGPSAWQEPGSTTDLFILNLAVADLCFILCCVPFQATIYTLDAWLFGALVCKAVHLLIYLTMYASSFTLAAVSVDRYLAVRHPLRSRALRTPRNARAAVGLVWLLAALFSAPYLSYYGTVRYGALELCVPAWEDARRRALDVATFAAGYLLPVAVVSLAYGRTLRFLWAAVGPAGAAAAEARRRATGRAGRAMLAVAALYALCWGPHHALILCFWYGRFAFSPATYACRLASHCLAYANSCLNPLVYALASRHFRARFRRLWPCGRRRRHRARRALRRVRPASSGPPGCPGDARPSGRLLAGGGQGPEPREGPVHGGEAARGPE
  
Inhibitor
Name:
BDBM89400
Synonyms:
2-[1-[5-(5-isoquinolyloxymethyl)isoxazole-3-carbonyl]-2-piperidyl]acetic acid ethyl ester | 2-[1-[[5-(5-isoquinolinyloxymethyl)-3-isoxazolyl]-oxomethyl]-2-piperidinyl]acetic acid ethyl ester | MLS001126596 | SMR000654747 | cid_24792017 | ethyl 2-[1-[5-(isoquinolin-5-yloxymethyl)-1,2-oxazole-3-carbonyl]piperidin-2-yl]acetate | ethyl 2-[1-[[5-(isoquinolin-5-yloxymethyl)-1,2-oxazol-3-yl]carbonyl]piperidin-2-yl]ethanoate
Type:
Small organic molecule
Emp. Form.:
C23H25N3O5
Mol. Mass.:
423.4617
SMILES:
CCOC(=O)CC1CCCCN1C(=O)c1cc(COc2cccc3cnccc23)on1
Structure:
Search PDB for entries with ligand similarity: