Target
Activin receptor type-1B
Ligand
BDBM280366
Substrate
n/a
Meas. Tech.
In Vitro Kinase Assay Inhibition of ALK1/2/3/4/5/6 Kinases
IC50
2.70±n/a nM
Citation
 Rai, RChakravarty, SPujala, BShinde, BUNayak, AKChaklan, NAgarwal, AKRamachandran, SAPham, SM Compounds and methods of use US Patent  US10030004 Publication Date 7/24/2018 
Target
Name:
Activin receptor type-1B
Synonyms:
ACV1B_HUMAN | ACVR1B | ACVRLK4 | ALK4 | Activin receptor type-1B/Activin receptor-like kinase 4 (ALK-4)
Type:
PROTEIN
Mol. Mass.:
56810.99
Organism:
Homo sapiens (Human)
Description:
ChEMBL_587064
Residue:
505
Sequence:
MAESAGASSFFPLVVLLLAGSGGSGPRGVQALLCACTSCLQANYTCETDGACMVSIFNLDGMEHHVRTCIPKVELVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHPSMWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQRVYHNRQRLDMEDPSCEMCLSKDKTLQDLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSGGVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTLSQLSVQEDVKI
  
Inhibitor
Name:
BDBM280366
Synonyms:
2-(5-chloro-2-fluorophenyl)-5-cyclopropyl-N-{1H-pyrrolo[2,3-b]pyridin-4-yl}pyridin-4-amine | US10030004, Compound 32 | US10501436, Compound 32 | US11053216, Compound 32 | US11702401, Compound 32
Type:
Small organic molecule
Emp. Form.:
C21H16ClFN4
Mol. Mass.:
378.83
SMILES:
Fc1ccc(Cl)cc1-c1cc(Nc2ccnc3[nH]ccc23)c(cn1)C1CC1
Structure:
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