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Target
Kallikrein-7
Ligand
BDBM100064
Substrate
n/a
EC50
>69513±n/a nM
Citation
 PubChem, PC Fluorescence Intensity-based biochemical primary high throughput dose response assay to identify activators of kallikrein-7 (K7) zymogen PubChem Bioassay (2013)[AID] 
Target
Name:
Kallikrein-7
Synonyms:
KLK7 | KLK7_HUMAN | Kallikrein 7 | Kallikrein-7 | PRSS6 | SCCE | Serine protease 6 | Stratum corneum chymotryptic enzyme | hK7 | hSCCE | kallikrein-7 isoform 1 preproprotein
Type:
PROTEIN
Mol. Mass.:
27535.05
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1469257
Residue:
253
Sequence:
MARSLLLPLQILLLSLALETAGEEAQGDKIIDGAPCARGSHPWQVALLSGNQLHCGGVLVNERWVLTAAHCKMNEYTVHLGSDTLGDRRAQRIKASKSFRHPGYSTQTHVNDLMLVKLNSQARLSSMVKKVRLPSRCEPPGTTCTVSGWGTTTSPDVTFPSDLMCVDVKLISPQDCTKVYKDLLENSMLCAGIPDSKKNACNGDSGGPLVCRGTLQGLVSWGTFPCGQPNDPGVYTQVCKFTKWINDTMKKHR
  
Inhibitor
Name:
BDBM100064
Synonyms:
5-keto-2-[(E)-3-phenylacryloyl]imino-1-(tetrahydrofurfuryl)dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxylic acid ethyl ester | 5-oxo-1-(2-oxolanylmethyl)-2-[(E)-1-oxo-3-phenylprop-2-enyl]imino-3-dipyrido[1,2-d:3',4'-f]pyrimidinecarboxylic acid ethyl ester | MLS000729833 | SMR000308110 | cid_16193091 | ethyl (2Z)-5-oxo-2-{[(2E)-3-phenylprop-2-enoyl]imino}-1-(tetrahydrofuran-2-ylmethyl)-1,5-dihydro-2H-dipyrido[1,2-a:2',3'-d]pyrimidine-3-carboxylate | ethyl 5-oxidanylidene-1-(oxolan-2-ylmethyl)-2-[(E)-3-phenylprop-2-enoyl]imino-dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxylate | ethyl 5-oxo-1-(oxolan-2-ylmethyl)-2-[(E)-3-phenylprop-2-enoyl]iminodipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxylate
Type:
Small organic molecule
Emp. Form.:
C28H26N4O5
Mol. Mass.:
498.5298
SMILES:
CCOC(=O)c1cc2c(nc3ccccn3c2=O)n(CC2CCCO2)\c1=N\C(=O)\C=C\c1ccccc1
Structure:
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