Reaction Details Report a problem with these data
Target
Kallikrein-7
Ligand
BDBM100141
Substrate
n/a
EC50
21666±n/a nM
Citation
 PubChem, PC Fluorescence Intensity-based biochemical primary high throughput dose response assay to identify activators of kallikrein-7 (K7) zymogen PubChem Bioassay (2013)[AID] 
Target
Name:
Kallikrein-7
Synonyms:
KLK7 | KLK7_HUMAN | Kallikrein 7 | Kallikrein-7 | PRSS6 | SCCE | Serine protease 6 | Stratum corneum chymotryptic enzyme | hK7 | hSCCE | kallikrein-7 isoform 1 preproprotein
Type:
PROTEIN
Mol. Mass.:
27535.05
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1469257
Residue:
253
Sequence:
MARSLLLPLQILLLSLALETAGEEAQGDKIIDGAPCARGSHPWQVALLSGNQLHCGGVLVNERWVLTAAHCKMNEYTVHLGSDTLGDRRAQRIKASKSFRHPGYSTQTHVNDLMLVKLNSQARLSSMVKKVRLPSRCEPPGTTCTVSGWGTTTSPDVTFPSDLMCVDVKLISPQDCTKVYKDLLENSMLCAGIPDSKKNACNGDSGGPLVCRGTLQGLVSWGTFPCGQPNDPGVYTQVCKFTKWINDTMKKHR
  
Inhibitor
Name:
BDBM100141
Synonyms:
(2E)-3-(4-hydroxyphenyl)-2-[2-(4-ketocyclohexa-2,5-dien-1-ylidene)ethylidene]-1H-quinazolin-4-one | (2E)-3-(4-hydroxyphenyl)-2-[2-(4-oxidanylidenecyclohexa-2,5-dien-1-ylidene)ethylidene]-1H-quinazolin-4-one | (2E)-3-(4-hydroxyphenyl)-2-[2-(4-oxo-1-cyclohexa-2,5-dienylidene)ethylidene]-1H-quinazolin-4-one | (2E)-3-(4-hydroxyphenyl)-2-[2-(4-oxocyclohexa-2,5-dien-1-ylidene)ethylidene]-1H-quinazolin-4-one | 3-(4-Hydroxy-phenyl)-2-[2-(4-hydroxy-phenyl)-vinyl]-3H-quinazolin-4-one | MLS001197269 | SMR000555464 | cid_5346546
Type:
Small organic molecule
Emp. Form.:
C22H16N2O3
Mol. Mass.:
356.374
SMILES:
Oc1ccc(C=Cc2nc3ccccc3c(=O)n2-c2ccc(O)cc2)cc1 |w:6.6|
Structure:
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