Reaction Details Report a problem with these data
Target
Kallikrein-7
Ligand
BDBM100169
Substrate
n/a
EC50
>69485±n/a nM
Citation
 PubChem, PC Fluorescence Intensity-based biochemical primary high throughput dose response assay to identify activators of kallikrein-7 (K7) zymogen PubChem Bioassay (2013)[AID] 
Target
Name:
Kallikrein-7
Synonyms:
KLK7 | KLK7_HUMAN | Kallikrein 7 | Kallikrein-7 | PRSS6 | SCCE | Serine protease 6 | Stratum corneum chymotryptic enzyme | hK7 | hSCCE | kallikrein-7 isoform 1 preproprotein
Type:
PROTEIN
Mol. Mass.:
27535.05
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1469257
Residue:
253
Sequence:
MARSLLLPLQILLLSLALETAGEEAQGDKIIDGAPCARGSHPWQVALLSGNQLHCGGVLVNERWVLTAAHCKMNEYTVHLGSDTLGDRRAQRIKASKSFRHPGYSTQTHVNDLMLVKLNSQARLSSMVKKVRLPSRCEPPGTTCTVSGWGTTTSPDVTFPSDLMCVDVKLISPQDCTKVYKDLLENSMLCAGIPDSKKNACNGDSGGPLVCRGTLQGLVSWGTFPCGQPNDPGVYTQVCKFTKWINDTMKKHR
  
Inhibitor
Name:
BDBM100169
Synonyms:
4-ketospiro[1,3-dihydroquinazoline-2,4'-piperidine]-1'-carboxylic acid ethyl ester | 4-oxo-1'-spiro[1,3-dihydroquinazoline-2,4'-piperidine]carboxylic acid ethyl ester | MLS002920561 | SMR001798150 | cid_285503 | ethyl 4-oxidanylidenespiro[1,3-dihydroquinazoline-2,4'-piperidine]-1'-carboxylate | ethyl 4-oxospiro[1,3-dihydroquinazoline-2,4'-piperidine]-1'-carboxylate
Type:
Small organic molecule
Emp. Form.:
C15H19N3O3
Mol. Mass.:
289.3297
SMILES:
CCOC(=O)N1CCC2(CC1)NC(=O)c1ccccc1N2
Structure:
Search PDB for entries with ligand similarity: