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Target
Aldo-keto reductase family 1 member B1
Ligand
BDBM104024
Substrate
n/a
Meas. Tech.
IC50 Activity Assays
pH
7±n/a
Temperature
298.15±n/a K
IC50
1.9e+2± 9e+1 nM
Citation
 Fanfrlík, J; Fanfrlík, M; Kolár, M; Hurný, D; Hurný, FX; Cousido-Siah, A; Mitschler, A; Rezác, J; Rezác, E; Lep?ík, M; Lepšík, P; Matejícek, J; Veselý, A; Hobza, P Modulation of aldose reductase inhibition by halogen bond tuning. ACS Chem Biol 8:2484-92 (2013) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1
Synonyms:
AKR1B1 | ALDR1 | ALDR_HUMAN | ALR2 | AR | Aldo-keto reductase family 1 member B1 (AKR1B1) | Aldose Reductase (ALR2) | Aldose reductase | Aldose reductase (AR)
Type:
Protein
Mol. Mass.:
35855.50
Organism:
Homo sapiens (Human)
Description:
P15121. 4LAU; 2IKI; 4LB4; 2FZD; 2FZ8; 1US0
Residue:
316
Sequence:
MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCALLSCTSHKDYPFHEEF
  
Inhibitor
Name:
BDBM104024
Synonyms:
MK315
Type:
Small organic molecule
Emp. Form.:
C16H12ClFINO4
Mol. Mass.:
463.627
SMILES:
OC(=O)COc1cc(Cl)ccc1C(=O)NCc1ccc(I)cc1F
Structure:
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