Reaction Details Report a problem with these data
Target
Angiogenin
Ligand
BDBM111447
Substrate
n/a
Meas. Tech.
Inhibition Kinetics with Angiogenin
pH
6±n/a
Ki
1.114e+6± 3e+3 nM
Comments
extracted
Citation
 Debnath, J; Dasgupta, S; Pathak, T Amino and carboxy functionalized modified nucleosides: a potential class of inhibitors for angiogenin. Bioorg Chem 52:56-61 (2014) [PubMed]  Article 
Target
Name:
Angiogenin
Synonyms:
ANG | ANGI_HUMAN | RNASE5
Type:
Protein
Mol. Mass.:
16563.00
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
147
Sequence:
MVMGLGVLLLVFVLGLGLTPPTLAQDNSRYTHFLTQHYDAKPQGRDDRYCESIMRRRGLTSPCKDINTFIHGNKRSIKAICENKNGNPHRENLRISKSSFQVTTCKLHGGSPWPPCQYRATAGFRNVVVACENGLPVHLDQSIFRRP
  
Inhibitor
Name:
BDBM111447
Synonyms:
N-[2-Hydroxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro- 2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-malonamic acid (Compound 6)
Type:
Small organic molecule
Emp. Form.:
C13H17N3O7
Mol. Mass.:
327.29
SMILES:
Cc1cn([C@H]2C[C@@H](NC(=O)CC(O)=O)[C@@H](CO)O2)c(=O)[nH]c1=O |r|
Structure:
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