Target
Tyrosine-protein kinase JAK3
Ligand
BDBM112607
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
7.2±n/a
Ki
0.00679±n/a nM
IC50
0.013595±n/a nM
Citation
 de Vicente Fidalgo, JHermann, JCLemoine, RLi, HLovey, AJSjogren, EBSoth, M Inhibitors of JAK US Patent  US8618103 Publication Date 12/31/2013 
Target
Name:
Tyrosine-protein kinase JAK3
Synonyms:
JAK-3 | JAK3 | JAK3_HUMAN | Janus kinase 3 | Janus kinase 3 (JAK3) | Janus kinase 3 JAK3 | L-JAK | Leukocyte janus kinase
Type:
Protein
Mol. Mass.:
125111.08
Organism:
Homo sapiens (Human)
Description:
P52333
Residue:
1124
Sequence:
MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS
  
Inhibitor
Name:
BDBM112607
Synonyms:
US8618103, I-103
Type:
Small organic molecule
Emp. Form.:
C23H29N9O2S
Mol. Mass.:
495.6
SMILES:
CS(=O)(=O)N1CCC[C@@H](C1)Nc1nc(NC2CCC(CC2)C#N)ncc1-c1cnc2[nH]ccc2n1 |r,wD:8.10,(4.63,8.38,;4.23,6.89,;5.71,7.29,;3.14,7.98,;3.83,5.41,;4.92,4.32,;4.52,2.83,;3.03,2.43,;1.94,3.52,;2.34,5.01,;.45,3.12,;.06,1.63,;1.15,.54,;.75,-.94,;1.84,-2.03,;1.44,-3.52,;-.05,-3.92,;-.45,-5.41,;.64,-6.49,;2.13,-6.1,;2.53,-4.61,;.24,-7.98,;-1.25,-8.38,;-.74,-1.34,;-1.83,-.25,;-1.43,1.23,;-2.52,2.32,;-3.98,1.85,;-5.13,2.88,;-4.81,4.38,;-5.71,5.63,;-4.81,6.88,;-3.34,6.4,;-3.34,4.86,;-2.2,3.83,)|
Structure:
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