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Target
Disintegrin and metalloproteinase domain-containing protein 17
Ligand
BDBM113937
Substrate
n/a
Meas. Tech.
Counterscreen for exosite inhibitors of ADAM10: QFRET-based biochemical high throughput dose response assay to identify inhibitors of ADAM17
IC50
69488±n/a nM
Citation
 PubChem, PC Counterscreen for exosite inhibitors of ADAM10: QFRET-based biochemical high throughput dose response assay to identify inhibitors of ADAM17 PubChem Bioassay (2014)[AID] 
Target
Name:
Disintegrin and metalloproteinase domain-containing protein 17
Synonyms:
ADA17_HUMAN | ADAM17 | CSVP | Disintegrin and metalloproteinase domain-containing protein 17 (ADAM-17) | Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17) | TACE | TNF-alpha convertase | TNF-alpha converting enzyme (TACE) | TNF-alpha-converting enzyme (TACE) | Tumor Necrosis Factor Alpha Converting Enzyme | Tumor necrosis factor-α converting enzyme (TACE)
Type:
Enzyme
Mol. Mass.:
93007.89
Organism:
Homo sapiens (Human)
Description:
Residue:
824
Sequence:
MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERFSQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQSPKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNAGFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMFSNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINATCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFLRKGKPCTVGFCDMNGKCEKRVQDVIERFWDFIDQLSINTFGKFLADNIVGSVLVFSLIFWIPFSILVHCVDKKLDKQYESLSLFHPSNVEMLSSMDSASVRIIKPFPAPQTPGRLQPAPVIPSAPAAPKLDHQRMDTIQEDPSTDSHMDEDGFEKDPFPNSSTAAKSFEDLTDHPVTRSEKAASFKLQRQNRVDSKETEC
  
Inhibitor
Name:
BDBM113937
Synonyms:
3-[(3R,4S)-2-(4-bromophenyl)-5-(4-fluorophenyl)-4-(4-nitrophenyl)-2-pyrazoline-3-carbonyl]oxazolidin-2-one | 3-[(3R,4S)-2-(4-bromophenyl)-5-(4-fluorophenyl)-4-(4-nitrophenyl)-3,4-dihydropyrazole-3-carbonyl]-1,3-oxazolidin-2-one | 3-[[(3R,4S)-2-(4-bromophenyl)-5-(4-fluorophenyl)-4-(4-nitrophenyl)-3,4-dihydropyrazol-3-yl]-oxomethyl]-2-oxazolidinone | 3-[[(3R,4S)-2-(4-bromophenyl)-5-(4-fluorophenyl)-4-(4-nitrophenyl)-3,4-dihydropyrazol-3-yl]carbonyl]-1,3-oxazolidin-2-one | MLS000517953 | SMR000327285 | cid_16060024
Type:
Small organic molecule
Emp. Form.:
C25H18BrFN4O5
Mol. Mass.:
553.337
SMILES:
[O-][N+](=O)c1ccc(cc1)[C@@H]1[C-](N[N+](=C1C(=O)N1CCOC1=O)c1ccc(Br)cc1)c1ccc(F)cc1 |c:13|
Structure:
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