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Target
Disintegrin and metalloproteinase domain-containing protein 10
Ligand
BDBM113864
Substrate
n/a
Meas. Tech.
QFRET-based biochemical high throughput dose response assay to identify exosite inhibitors of ADAM10.
IC50
7694±n/a nM
Citation
 PubChem, PC QFRET-based biochemical high throughput dose response assay to identify exosite inhibitors of ADAM10. PubChem Bioassay (2014)[AID] 
Target
Name:
Disintegrin and metalloproteinase domain-containing protein 10
Synonyms:
ADA10_HUMAN | ADAM10 | Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) | KUZ | MADM
Type:
Enzyme
Mol. Mass.:
84160.93
Organism:
Homo sapiens (Human)
Description:
O14672
Residue:
748
Sequence:
MVLLRVLILLLSWAAGMGGQYGNPLNKYIRHYEGLSYNVDSLHQKHQRAKRAVSHEDQFLRLDFHAHGRHFNLRMKRDTSLFSDEFKVETSNKVLDYDTSHIYTGHIYGEEGSFSHGSVIDGRFEGFIQTRGGTFYVEPAERYIKDRTLPFHSVIYHEDDINYPHKYGPQGGCADHSVFERMRKYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQTDHLFFKYYGTREAVIAQISSHVKAIDTIYQTTDFSGIRNISFMVKRIRINTTADEKDPTNPFRFPNIGVEKFLELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNTGIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIMYARATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQCKDECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDDSDCAREGICNGFTALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKYGLEECTCASSDGKDDKELCHVCCMKKMDPSTCASTGSVQWSRHFSGRTITLQPGSPCNDFRGYCDVFMRCRLVDADGPLARLKKAIFSPELYENIAEWIVAHWWAVLLMGIALIMLMAGFIKICSVHTPSSNPKLPPPKPLPGTLKRRRPPQPIQQPQRQRPRESYQMGHMRR
  
Inhibitor
Name:
BDBM113864
Synonyms:
2-[(4-Cyclohexylsulfamoyl-benzenesulfonyl)-thiophen-2-ylmethyl-amino]-N-phenyl-acetamide | 2-[[4-(cyclohexylsulfamoyl)phenyl]sulfonyl-(2-thenyl)amino]-N-phenyl-acetamide | 2-[[4-(cyclohexylsulfamoyl)phenyl]sulfonyl-(thiophen-2-ylmethyl)amino]-N-phenyl-ethanamide | 2-[[4-(cyclohexylsulfamoyl)phenyl]sulfonyl-(thiophen-2-ylmethyl)amino]-N-phenylacetamide | MLS000548357 | SMR000171048 | cid_3202196
Type:
Small organic molecule
Emp. Form.:
C25H29N3O5S3
Mol. Mass.:
547.71
SMILES:
O=C(CN(Cc1cccs1)S(=O)(=O)c1ccc(cc1)S(=O)(=O)NC1CCCCC1)Nc1ccccc1
Structure:
Search PDB for entries with ligand similarity: