Target
Disintegrin and metalloproteinase domain-containing protein 10
Ligand
BDBM68053
Substrate
n/a
Meas. Tech.
QFRET-based biochemical high throughput dose response assay to identify exosite inhibitors of ADAM10.
IC50
7726±n/a nM
Citation
 PubChem, PC QFRET-based biochemical high throughput dose response assay to identify exosite inhibitors of ADAM10. PubChem Bioassay (2014)[AID] 
Target
Name:
Disintegrin and metalloproteinase domain-containing protein 10
Synonyms:
ADA10_HUMAN | ADAM10 | Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) | KUZ | MADM
Type:
Enzyme
Mol. Mass.:
84160.93
Organism:
Homo sapiens (Human)
Description:
O14672
Residue:
748
Sequence:
MVLLRVLILLLSWAAGMGGQYGNPLNKYIRHYEGLSYNVDSLHQKHQRAKRAVSHEDQFLRLDFHAHGRHFNLRMKRDTSLFSDEFKVETSNKVLDYDTSHIYTGHIYGEEGSFSHGSVIDGRFEGFIQTRGGTFYVEPAERYIKDRTLPFHSVIYHEDDINYPHKYGPQGGCADHSVFERMRKYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQTDHLFFKYYGTREAVIAQISSHVKAIDTIYQTTDFSGIRNISFMVKRIRINTTADEKDPTNPFRFPNIGVEKFLELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNTGIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIMYARATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQCKDECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDDSDCAREGICNGFTALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKYGLEECTCASSDGKDDKELCHVCCMKKMDPSTCASTGSVQWSRHFSGRTITLQPGSPCNDFRGYCDVFMRCRLVDADGPLARLKKAIFSPELYENIAEWIVAHWWAVLLMGIALIMLMAGFIKICSVHTPSSNPKLPPPKPLPGTLKRRRPPQPIQQPQRQRPRESYQMGHMRR
  
Inhibitor
Name:
BDBM68053
Synonyms:
3-amino-2-N-(3-chlorophenyl)-4-N-(2-methoxyphenyl)-5-(2-methylanilino)thiophene-2,4-dicarboxamide | 3-amino-N-(3-chlorophenyl)-N'-(2-methoxyphenyl)-5-(o-toluidino)thiophene-2,4-dicarboxamide | 3-amino-N2-(3-chlorophenyl)-N4-(2-methoxyphenyl)-5-(2-methylanilino)thiophene-2,4-dicarboxamide | 3-azanyl-N2-(3-chlorophenyl)-N4-(2-methoxyphenyl)-5-[(2-methylphenyl)amino]thiophene-2,4-dicarboxamide | MLS000394900 | SMR000262185 | cid_2439674
Type:
Small organic molecule
Emp. Form.:
C26H23ClN4O3S
Mol. Mass.:
507.004
SMILES:
COc1ccccc1NC(=O)c1c(N)c(sc1Nc1ccccc1C)C(=O)Nc1cccc(Cl)c1
Structure:
Search PDB for entries with ligand similarity: