Reaction Details Report a problem with these data
Target
Tyrosyl-DNA phosphodiesterase 2
Ligand
BDBM61179
Substrate
n/a
Meas. Tech.
Epi Absorbance-based biochemical high throughput dose response assay to identify inhibitors of human tyrosyl-DNA phosphodiesterase 2 (TDP2)
IC50
6561±n/a nM
Citation
 PubChem, PC Epi Absorbance-based biochemical high throughput dose response assay to identify inhibitors of human tyrosyl-DNA phosphodiesterase 2 (TDP2) PubChem Bioassay (2014)[AID] 
Target
Name:
Tyrosyl-DNA phosphodiesterase 2
Synonyms:
EAP2 | EAPII | ETS1-associated protein 2 | ETS1-associated protein II | TDP2 | TRAF and TNF receptor-associated protein | TTRAP | TYDP2_HUMAN | Tyr-DNA phosphodiesterase 2 | Tyrosyl-DNA phosphodiesterase 2 | Tyrosyl-DNA phosphodiesterase 2 (hTDP2) | Tyrosyl-RNA phosphodiesterase | VPg unlinkase | hTDP2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
40916.54
Organism:
Homo sapiens (Human)
Description:
gi_23510348
Residue:
362
Sequence:
MELGSCLEGGREAAEEEGEPEVKKRRLLCVEFASVASCDAAVAQCFLAENDWEMERALNSYFEPPVEESALERRPETISEPKTYVDLTNEETTDSTTSKISPSEDTQQENGSMFSLITWNIDGLDLNNLSERARGVCSYLALYSPDVIFLQEVIPPYYSYLKKRSSNYEIITGHEEGYFTAIMLKKSRVKLKSQEIIPFPSTKMMRNLLCVHVNVSGNELCLMTSHLESTRGHAAERMNQLKMVLKKMQEAPESATVIFAGDTNLRDREVTRCGGLPNNIVDVWEFLGKPKHCQYTWDTQMNSNLGITAACKLRFDRIFFRAAAEEGHIIPRSLDLLGLEKLDCGRFPSDHWGLLCNLDIIL
  
Inhibitor
Name:
BDBM61179
Synonyms:
2-(3,4-Dioxo-3,4-dihydro-naphthalen-1-ylamino)-benzoic acid | 2-[(3,4-diketo-1-naphthyl)amino]benzoic acid | 2-[(3,4-dioxo-1-naphthalenyl)amino]benzoic acid | 2-[(3,4-dioxonaphthalen-1-yl)amino]benzoic acid | 2-[[3,4-bis(oxidanylidene)naphthalen-1-yl]amino]benzoic acid | MLS000123143 | SMR000123743 | cid_3095208
Type:
Small organic molecule
Emp. Form.:
C17H11NO4
Mol. Mass.:
293.2735
SMILES:
OC(=O)c1ccccc1NC1=CC(=O)C(=O)c2ccccc12 |t:11|
Structure:
Search PDB for entries with ligand similarity: