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Target
Tyrosyl-DNA phosphodiesterase 2
Ligand
BDBM64796
Substrate
n/a
Meas. Tech.
Epi Absorbance-based biochemical high throughput dose response assay to identify inhibitors of human tyrosyl-DNA phosphodiesterase 2 (TDP2)
IC50
3847±n/a nM
Citation
 PubChem, PC Epi Absorbance-based biochemical high throughput dose response assay to identify inhibitors of human tyrosyl-DNA phosphodiesterase 2 (TDP2) PubChem Bioassay (2014)[AID] 
Target
Name:
Tyrosyl-DNA phosphodiesterase 2
Synonyms:
EAP2 | EAPII | ETS1-associated protein 2 | ETS1-associated protein II | TDP2 | TRAF and TNF receptor-associated protein | TTRAP | TYDP2_HUMAN | Tyr-DNA phosphodiesterase 2 | Tyrosyl-DNA phosphodiesterase 2 | Tyrosyl-DNA phosphodiesterase 2 (hTDP2) | Tyrosyl-RNA phosphodiesterase | VPg unlinkase | hTDP2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
40916.54
Organism:
Homo sapiens (Human)
Description:
gi_23510348
Residue:
362
Sequence:
MELGSCLEGGREAAEEEGEPEVKKRRLLCVEFASVASCDAAVAQCFLAENDWEMERALNSYFEPPVEESALERRPETISEPKTYVDLTNEETTDSTTSKISPSEDTQQENGSMFSLITWNIDGLDLNNLSERARGVCSYLALYSPDVIFLQEVIPPYYSYLKKRSSNYEIITGHEEGYFTAIMLKKSRVKLKSQEIIPFPSTKMMRNLLCVHVNVSGNELCLMTSHLESTRGHAAERMNQLKMVLKKMQEAPESATVIFAGDTNLRDREVTRCGGLPNNIVDVWEFLGKPKHCQYTWDTQMNSNLGITAACKLRFDRIFFRAAAEEGHIIPRSLDLLGLEKLDCGRFPSDHWGLLCNLDIIL
  
Inhibitor
Name:
BDBM64796
Synonyms:
MLS000861878 | N-(2-hydroxy-1,3-diketo-indan-2-yl)-4-(trifluoromethyl)benzamide | N-(2-hydroxy-1,3-dioxo-2-indenyl)-4-(trifluoromethyl)benzamide | N-(2-hydroxy-1,3-dioxoinden-2-yl)-4-(trifluoromethyl)benzamide | N-[2-oxidanyl-1,3-bis(oxidanylidene)inden-2-yl]-4-(trifluoromethyl)benzamide | N1-(2-hydroxy-1,3-dioxo-2,3-dihydro-1H-inden-2-yl)-4-(trifluoromethyl)benzamide | SMR000460662 | cid_2732881
Type:
Small organic molecule
Emp. Form.:
C17H10F3NO4
Mol. Mass.:
349.2608
SMILES:
OC1(NC(=O)c2ccc(cc2)C(F)(F)F)C(=O)c2ccccc2C1=O
Structure:
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