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Target
Major prion protein
Ligand
BDBM42607
Substrate
n/a
Meas. Tech.
TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC)
IC50
1907±n/a nM
Citation
 PubChem, PC TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC) PubChem Bioassay (2014)[AID] 
Target
Name:
Major prion protein
Synonyms:
ALTPRP | ASCR | CD_antigen=CD230 | PRIO_HUMAN | PRIP | PRNP | PRP | PrP27-30 | PrP33-35C | Prion protein | major prion protein preproprotein
Type:
PROTEIN
Mol. Mass.:
27671.97
Organism:
Homo sapiens (Human)
Description:
ChEMBL_158887
Residue:
253
Sequence:
MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG
  
Inhibitor
Name:
BDBM42607
Synonyms:
2-(6-Bromo-quinazolin-4-ylamino)-4-methylsulfanyl-butyric acid | 2-[(6-bromanylquinazolin-4-yl)amino]-4-methylsulfanyl-butanoic acid;hydrochloride | 2-[(6-bromo-4-quinazolinyl)amino]-4-(methylthio)butanoic acid;hydrochloride | 2-[(6-bromoquinazolin-4-yl)amino]-4-(methylthio)butyric acid;hydrochloride | 2-[(6-bromoquinazolin-4-yl)amino]-4-methylsulfanylbutanoic acid;hydrochloride | MLS000032173 | SMR000011110 | cid_2787398
Type:
Small organic molecule
Emp. Form.:
C13H14BrN3O2S
Mol. Mass.:
356.238
SMILES:
CSCCC(Nc1ncnc2ccc(Br)cc12)C(O)=O
Structure:
Search PDB for entries with ligand similarity: