Reaction Details Report a problem with these data
Target
Major prion protein
Ligand
BDBM42791
Substrate
n/a
Meas. Tech.
TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC)
IC50
1025±n/a nM
Citation
 PubChem, PC TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC) PubChem Bioassay (2014)[AID] 
Target
Name:
Major prion protein
Synonyms:
ALTPRP | ASCR | CD_antigen=CD230 | PRIO_HUMAN | PRIP | PRNP | PRP | PrP27-30 | PrP33-35C | Prion protein | major prion protein preproprotein
Type:
PROTEIN
Mol. Mass.:
27671.97
Organism:
Homo sapiens (Human)
Description:
ChEMBL_158887
Residue:
253
Sequence:
MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG
  
Inhibitor
Name:
BDBM42791
Synonyms:
2-[(4-fluorobenzyl)thio]-4-(2-furyl)-6-oxo-1,6-dihydro-5-pyrimidinecarbonitrile | 2-[(4-fluorobenzyl)thio]-6-(2-furyl)-4-keto-1H-pyrimidine-5-carbonitrile | 2-[(4-fluorophenyl)methylsulfanyl]-6-(furan-2-yl)-4-oxidanylidene-1H-pyrimidine-5-carbonitrile | 2-[(4-fluorophenyl)methylsulfanyl]-6-(furan-2-yl)-4-oxo-1H-pyrimidine-5-carbonitrile | 2-[(4-fluorophenyl)methylthio]-6-(2-furanyl)-4-oxo-1H-pyrimidine-5-carbonitrile | MLS000065058 | SMR000078436 | cid_974019
Type:
Small organic molecule
Emp. Form.:
C16H10FN3O2S
Mol. Mass.:
327.333
SMILES:
Fc1ccc(CSc2nc(-c3ccco3)c(C#N)c(=O)[nH]2)cc1
Structure:
Search PDB for entries with ligand similarity: