Reaction Details Report a problem with these data
Target
Major prion protein
Ligand
BDBM114429
Substrate
n/a
Meas. Tech.
TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC)
IC50
1980±n/a nM
Citation
 PubChem, PC TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC) PubChem Bioassay (2014)[AID] 
Target
Name:
Major prion protein
Synonyms:
ALTPRP | ASCR | CD_antigen=CD230 | PRIO_HUMAN | PRIP | PRNP | PRP | PrP27-30 | PrP33-35C | Prion protein | major prion protein preproprotein
Type:
PROTEIN
Mol. Mass.:
27671.97
Organism:
Homo sapiens (Human)
Description:
ChEMBL_158887
Residue:
253
Sequence:
MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG
  
Inhibitor
Name:
BDBM114429
Synonyms:
4-Methoxy-benzoic acid N'-[2-(2-isopropyl-quinazolin-4-ylsulfanyl)-acetyl]-hydrazide | 4-methoxy-N'-[1-oxo-2-[(2-propan-2-yl-4-quinazolinyl)thio]ethyl]benzohydrazide | 4-methoxy-N'-[2-(2-propan-2-ylquinazolin-4-yl)sulfanylacetyl]benzohydrazide | 4-methoxy-N'-[2-(2-propan-2-ylquinazolin-4-yl)sulfanylethanoyl]benzohydrazide | MLS001221823 | N'-[2-[(2-isopropylquinazolin-4-yl)thio]acetyl]-4-methoxy-benzohydrazide | SMR000607289 | cid_24793479
Type:
Small organic molecule
Emp. Form.:
C21H22N4O3S
Mol. Mass.:
410.489
SMILES:
COc1ccc(cc1)C(=O)NNC(=O)CSc1nc(nc2ccccc12)C(C)C
Structure:
Search PDB for entries with ligand similarity: