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Target
Group 3 secretory phospholipase A2
Ligand
BDBM65999
Substrate
n/a
Meas. Tech.
QFRET-based biochemical high throughput dose response assay to identify inhibitors of human group III secreted phospholipase A2 enzyme (HGIII-sPLA2)
IC50
34908±n/a nM
Citation
 PubChem, PC QFRET-based biochemical high throughput dose response assay to identify inhibitors of human group III secreted phospholipase A2 enzyme (HGIII-sPLA2) PubChem Bioassay (2014)[AID] 
Target
Name:
Group 3 secretory phospholipase A2
Synonyms:
3.1.1.4 | GIII sPLA2 | Group III secretory phopholipase A2 | Group III secretory phospholipase A2 | PA2G3_HUMAN | PLA2G3 | Phosphatidylcholine 2-acylhydrolase 3 | phospholipase A2, group III | sPLA2-III
Type:
PROTEIN
Mol. Mass.:
57196.58
Organism:
Homo sapiens
Description:
ChEMBL_119722
Residue:
509
Sequence:
MGVQAGLFGMLGFLGVALGGSPALRWYRTSCHLTKAVPGNPLGYLSFLAKDAQGLALIHARWDAHRRLQSCSWEDEPELTAAYGALCAHETAWGSFIHTPGPELQRALATLQSQWEACRALEESPAGARKKRAAGQSGVPGGGHQREKRGWTMPGTLWCGVGDSAGNSSELGVFQGPDLCCREHDRCPQNISPLQYNYGIRNYRFHTISHCDCDTRFQQCLQNQHDSISDIVGVAFFNVLEIPCFVLEEQEACVAWYWWGGCRMYGTVPLARLQPRTFYNASWSSRATSPTPSSRSPAPPKPRQKQHLRKGPPHQKGSKRPSKANTTALQDPMVSPRLDVAPTGLQGPQGGLKPQGARWVCRSFRRHLDQCEHQIGPREIEFQLLNSAQEPLFHCNCTRRLARFLRLHSPPEVTNMLWELLGTTCFKLAPPLDCVEGKNCSRDPRAIRVSARHLRRLQQRRHQLQDKGTDERQPWPSEPLRGPMSFYNQCLQLTQAARRPDRQQKSWSQ
  
Inhibitor
Name:
BDBM65999
Synonyms:
MLS000702907 | N-({2-[2-(4-chlorophenoxy)propanoyl]hydrazino}carbothioyl)-2-furamide | N-[[2-(4-chloranylphenoxy)propanoylamino]carbamothioyl]furan-2-carboxamide | N-[[2-(4-chlorophenoxy)propanoylamino]carbamothioyl]furan-2-carboxamide | N-[[2-(4-chlorophenoxy)propanoylamino]thiocarbamoyl]-2-furamide | N-[[[2-(4-chlorophenoxy)-1-oxopropyl]hydrazo]-sulfanylidenemethyl]-2-furancarboxamide | SMR000227560 | cid_5021903
Type:
Small organic molecule
Emp. Form.:
C15H14ClN3O4S
Mol. Mass.:
367.807
SMILES:
CC(Oc1ccc(Cl)cc1)C(=O)NNC(=S)NC(=O)c1ccco1
Structure:
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