Reaction Details Report a problem with these data
Target
Group 3 secretory phospholipase A2
Ligand
BDBM114203
Substrate
n/a
Meas. Tech.
QFRET-based biochemical high throughput dose response assay to identify inhibitors of human group III secreted phospholipase A2 enzyme (HGIII-sPLA2)
IC50
36129±n/a nM
Citation
 PubChem, PC QFRET-based biochemical high throughput dose response assay to identify inhibitors of human group III secreted phospholipase A2 enzyme (HGIII-sPLA2) PubChem Bioassay (2014)[AID] 
Target
Name:
Group 3 secretory phospholipase A2
Synonyms:
3.1.1.4 | GIII sPLA2 | Group III secretory phopholipase A2 | Group III secretory phospholipase A2 | PA2G3_HUMAN | PLA2G3 | Phosphatidylcholine 2-acylhydrolase 3 | phospholipase A2, group III | sPLA2-III
Type:
PROTEIN
Mol. Mass.:
57196.58
Organism:
Homo sapiens
Description:
ChEMBL_119722
Residue:
509
Sequence:
MGVQAGLFGMLGFLGVALGGSPALRWYRTSCHLTKAVPGNPLGYLSFLAKDAQGLALIHARWDAHRRLQSCSWEDEPELTAAYGALCAHETAWGSFIHTPGPELQRALATLQSQWEACRALEESPAGARKKRAAGQSGVPGGGHQREKRGWTMPGTLWCGVGDSAGNSSELGVFQGPDLCCREHDRCPQNISPLQYNYGIRNYRFHTISHCDCDTRFQQCLQNQHDSISDIVGVAFFNVLEIPCFVLEEQEACVAWYWWGGCRMYGTVPLARLQPRTFYNASWSSRATSPTPSSRSPAPPKPRQKQHLRKGPPHQKGSKRPSKANTTALQDPMVSPRLDVAPTGLQGPQGGLKPQGARWVCRSFRRHLDQCEHQIGPREIEFQLLNSAQEPLFHCNCTRRLARFLRLHSPPEVTNMLWELLGTTCFKLAPPLDCVEGKNCSRDPRAIRVSARHLRRLQQRRHQLQDKGTDERQPWPSEPLRGPMSFYNQCLQLTQAARRPDRQQKSWSQ
  
Inhibitor
Name:
BDBM114203
Synonyms:
4-[4-(dimethylamino)benzylidene]-1-methyl-pyrazol[1,5-a]indol-1-ium-2-carboxylic acid ethyl ester;triflate | 4-[[4-(dimethylamino)phenyl]methylidene]-1-methyl-2-pyrazolo[1,5-a]indol-1-iumcarboxylic acid ethyl ester;trifluoromethanesulfonate | MLS002702450 | SMR001566011 | cid_395179 | ethyl 4-[[4-(dimethylamino)phenyl]methylidene]-1-methyl-pyrazolo[1,5-a]indol-1-ium-2-carboxylate;tris(fluoranyl)methanesulfonate | ethyl 4-[[4-(dimethylamino)phenyl]methylidene]-1-methylpyrazolo[1,5-a]indol-1-ium-2-carboxylate;trifluoromethanesulfonate
Type:
Small organic molecule
Emp. Form.:
C23H24N3O2
Mol. Mass.:
374.455
SMILES:
CCOC(=O)c1cc2n([n+]1C)c1ccccc1c2=Cc1ccc(cc1)N(C)C
Structure:
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