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Target
5-hydroxytryptamine receptor 2A
Ligand
BDBM76106
Substrate
n/a
Meas. Tech.
Late stage for the probe development effort to identify agonists of the mouse 5-hydroxytryptamine (serotonin) receptor 2A (HTR2A)
EC50
3467±n/a nM
Citation
 PubChem, PC Late stage for the probe development effort to identify agonists of the mouse 5-hydroxytryptamine (serotonin) receptor 2A (HTR2A): Luminescence-based cell-based high throughput dose response assay for agonists of the mouse 5-hydroxytryptamine (serotonin) receptor 2A (HTR2A) PubChem Bioassay (2013)[AID] 
Target
Name:
5-hydroxytryptamine receptor 2A
Synonyms:
5-HT-2 | 5-HT-2A | 5-hydroxytryptamine receptor 2A | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_MOUSE | Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor | Htr2 | Htr2a | Serotonin 2a (5-HT2a) receptor
Type:
Enzyme
Mol. Mass.:
52843.00
Organism:
Mus musculus (Mouse)
Description:
P35363
Residue:
471
Sequence:
MEILCEDNISLSSIPNSLMQLGDDSRLYPNDFNSRDANTSEASNWTIDAENRTNLSCEGYLPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLSSFSFLPQSSLSSEKLFQRSIHREPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPTLAYKSSQLQVGQKKNSQEDAEPTANDCSMVTLGNQHSEEMCTDNIETVNEKVSCV
  
Inhibitor
Name:
BDBM76106
Synonyms:
6-(1-benzimidazolylmethyl)-4-(2,5-dimethylphenyl)-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylic acid methyl ester | 6-(benzimidazol-1-ylmethyl)-4-(2,5-dimethylphenyl)-2-keto-3,4-dihydro-1H-pyrimidine-5-carboxylic acid methyl ester | MLS000052786 | SMR000082609 | cid_2983279 | methyl 6-(1H-benzimidazol-1-ylmethyl)-4-(2,5-dimethylphenyl)-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate | methyl 6-(benzimidazol-1-ylmethyl)-4-(2,5-dimethylphenyl)-2-oxidanylidene-3,4-dihydro-1H-pyrimidine-5-carboxylate | methyl 6-(benzimidazol-1-ylmethyl)-4-(2,5-dimethylphenyl)-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate
Type:
Small organic molecule
Emp. Form.:
C22H22N4O3
Mol. Mass.:
390.4351
SMILES:
COC(=O)C1C(NC(=O)N=C1Cn1cnc2ccccc12)c1cc(C)ccc1C |c:9|
Structure:
Search PDB for entries with ligand similarity: