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Target
Methyl-CpG-binding domain protein 2
Ligand
BDBM114636
Substrate
n/a
Meas. Tech.
TRFRET-based biochemical high throughput dose response assay to identify inhibitors of 5-meCpG-binding domain protein 2 (MBD2)-DBD binding to methylated oligonucleotide
IC50
35124±n/a nM
Citation
 PubChem, PC TRFRET-based biochemical high throughput dose response assay to identify inhibitors of 5-meCpG-binding domain protein 2 (MBD2)-DBD binding to methylated oligonucleotide PubChem Bioassay (2013)[AID] 
Target
Name:
Methyl-CpG-binding domain protein 2
Synonyms:
MBD2 | MBD2_HUMAN | Methyl-CpG binding domain protein 2 | Methyl-CpG-binding domain protein 2 (MBD2)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
43278.74
Organism:
Homo sapiens (Human)
Description:
gi_21595776
Residue:
411
Sequence:
MRAHPGGGRCCPEQEEGESAAGGSGAGGDSAIEQGGQGSALAPSPVSGVRREGARGGGRGRGRWKQAGRGGGVCGRGRGRGRGRGRGRGRGRGRGRPPSGGSGLGGDGGGCGGGGSGGGGAPRREPVPFPSGSAGPGPRGPRATESGKRMDCPALPPGWKKEEVIRKSGLSAGKSDVYYFSPSGKKFRSKPQLARYLGNTVDLSSFDFRTGKMMPSKLQKNKQRLRNDPLNQNKGKPDLNTTLPIRQTASIFKQPVTKVTNHPSNKVKSDPQRMNEQPRQLFWEKRLQGLSASDVTEQIIKTMELPKGLQGVGPGSNDETLLSAVASALHTSSAPITGQVSAAVEKNPAVWLNTSQPLCKAFIVTDEDIRKQEERVQQVRKKLEEALMADILSRAADTEEMDIEMDSGDEA
  
Inhibitor
Name:
BDBM114636
Synonyms:
1-[(4-methylphenyl)methyl]-4-oxidanyl-3-(phenylmethyl)pyridin-2-one | 3-benzyl-4-hydroxy-1-(4-methylbenzyl)-2(1H)-pyridinone | 3-benzyl-4-hydroxy-1-(4-methylbenzyl)-2-pyridone | 3-benzyl-4-hydroxy-1-[(4-methylphenyl)methyl]pyridin-2-one | 4-hydroxy-1-[(4-methylphenyl)methyl]-3-(phenylmethyl)-2-pyridinone | MLS000721712 | SMR000335184 | cid_54687404
Type:
Small organic molecule
Emp. Form.:
C20H19NO2
Mol. Mass.:
305.3704
SMILES:
Cc1ccc(Cn2ccc(O)c(Cc3ccccc3)c2=O)cc1
Structure:
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