Target
Methyl-CpG-binding domain protein 2
Ligand
BDBM50699
Substrate
n/a
Meas. Tech.
TRFRET-based biochemical high throughput dose response assay to identify inhibitors of 5-meCpG-binding domain protein 2 (MBD2)-DBD binding to methylated oligonucleotide
IC50
4777±n/a nM
Citation
 PubChem, PC TRFRET-based biochemical high throughput dose response assay to identify inhibitors of 5-meCpG-binding domain protein 2 (MBD2)-DBD binding to methylated oligonucleotide PubChem Bioassay (2013)[AID] 
Target
Name:
Methyl-CpG-binding domain protein 2
Synonyms:
MBD2 | MBD2_HUMAN | Methyl-CpG binding domain protein 2 | Methyl-CpG-binding domain protein 2 (MBD2)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
43278.74
Organism:
Homo sapiens (Human)
Description:
gi_21595776
Residue:
411
Sequence:
MRAHPGGGRCCPEQEEGESAAGGSGAGGDSAIEQGGQGSALAPSPVSGVRREGARGGGRGRGRWKQAGRGGGVCGRGRGRGRGRGRGRGRGRGRGRPPSGGSGLGGDGGGCGGGGSGGGGAPRREPVPFPSGSAGPGPRGPRATESGKRMDCPALPPGWKKEEVIRKSGLSAGKSDVYYFSPSGKKFRSKPQLARYLGNTVDLSSFDFRTGKMMPSKLQKNKQRLRNDPLNQNKGKPDLNTTLPIRQTASIFKQPVTKVTNHPSNKVKSDPQRMNEQPRQLFWEKRLQGLSASDVTEQIIKTMELPKGLQGVGPGSNDETLLSAVASALHTSSAPITGQVSAAVEKNPAVWLNTSQPLCKAFIVTDEDIRKQEERVQQVRKKLEEALMADILSRAADTEEMDIEMDSGDEA
  
Inhibitor
Name:
BDBM50699
Synonyms:
(2Z,3Z)-2-[4-(3,4-dimethoxyphenyl)-3H-1,3-thiazol-2-ylidene]-3-(3-nitro-4-oxidanylidene-cyclohexa-2,5-dien-1-ylidene)propanenitrile | (2Z,3Z)-2-[4-(3,4-dimethoxyphenyl)-3H-1,3-thiazol-2-ylidene]-3-(3-nitro-4-oxocyclohexa-2,5-dien-1-ylidene)propanenitrile | (2Z,3Z)-2-[4-(3,4-dimethoxyphenyl)-3H-thiazol-2-ylidene]-3-(3-nitro-4-oxo-1-cyclohexa-2,5-dienylidene)propanenitrile | (2Z,3Z)-2-[4-(3,4-dimethoxyphenyl)-4-thiazolin-2-ylidene]-3-(4-keto-3-nitro-cyclohexa-2,5-dien-1-ylidene)propionitrile | (E)-2-[4-(3,4-Dimethoxy-phenyl)-thiazol-2-yl]-3-(4-hydroxy-3-nitro-phenyl)-acrylonitrile | MLS000777382 | SMR000413866 | cid_16682695
Type:
Small organic molecule
Emp. Form.:
C20H15N3O5S
Mol. Mass.:
409.415
SMILES:
COc1ccc(cc1OC)-c1csc([nH+]1)C(=C\[c-]1ccc(=O)c(c1)[N+]([O-])=O)\C#N
Structure:
Search PDB for entries with ligand similarity: