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Target
Methyl-CpG-binding domain protein 2
Ligand
BDBM97005
Substrate
n/a
Meas. Tech.
TRFRET-based biochemical high throughput dose response assay to identify inhibitors of 5-meCpG-binding domain protein 2 (MBD2)-DBD binding to methylated oligonucleotide
IC50
24315±n/a nM
Citation
 PubChem, PC TRFRET-based biochemical high throughput dose response assay to identify inhibitors of 5-meCpG-binding domain protein 2 (MBD2)-DBD binding to methylated oligonucleotide PubChem Bioassay (2013)[AID] 
Target
Name:
Methyl-CpG-binding domain protein 2
Synonyms:
MBD2 | MBD2_HUMAN | Methyl-CpG binding domain protein 2 | Methyl-CpG-binding domain protein 2 (MBD2)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
43278.74
Organism:
Homo sapiens (Human)
Description:
gi_21595776
Residue:
411
Sequence:
MRAHPGGGRCCPEQEEGESAAGGSGAGGDSAIEQGGQGSALAPSPVSGVRREGARGGGRGRGRWKQAGRGGGVCGRGRGRGRGRGRGRGRGRGRGRPPSGGSGLGGDGGGCGGGGSGGGGAPRREPVPFPSGSAGPGPRGPRATESGKRMDCPALPPGWKKEEVIRKSGLSAGKSDVYYFSPSGKKFRSKPQLARYLGNTVDLSSFDFRTGKMMPSKLQKNKQRLRNDPLNQNKGKPDLNTTLPIRQTASIFKQPVTKVTNHPSNKVKSDPQRMNEQPRQLFWEKRLQGLSASDVTEQIIKTMELPKGLQGVGPGSNDETLLSAVASALHTSSAPITGQVSAAVEKNPAVWLNTSQPLCKAFIVTDEDIRKQEERVQQVRKKLEEALMADILSRAADTEEMDIEMDSGDEA
  
Inhibitor
Name:
BDBM97005
Synonyms:
MLS001199163 | N',N'-diethyl-N-(2-pyridin-4-yl-[1,2,4]triazolo[1,5-c]quinazolin-5-yl)propane-1,3-diamine | N,N-diethyl-N'-(2-pyridin-4-yl[1,2,4]triazolo[1,5-c]quinazolin-5-yl)propane-1,3-diamine | SMR000563031 | cid_20880348 | diethyl-[3-[[2-(4-pyridyl)-[1,2,4]triazolo[1,5-c]quinazolin-5-yl]amino]propyl]amine
Type:
Small organic molecule
Emp. Form.:
C21H25N7
Mol. Mass.:
375.4701
SMILES:
CCN(CC)CCCNc1nc2ccccc2c2nc(nn12)-c1ccncc1
Structure:
Search PDB for entries with ligand similarity: