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Target
Methyl-CpG-binding domain protein 2
Ligand
BDBM114648
Substrate
n/a
Meas. Tech.
TRFRET-based biochemical high throughput dose response assay to identify inhibitors of 5-meCpG-binding domain protein 2 (MBD2)-DBD binding to methylated oligonucleotide
IC50
43749±n/a nM
Citation
 PubChem, PC TRFRET-based biochemical high throughput dose response assay to identify inhibitors of 5-meCpG-binding domain protein 2 (MBD2)-DBD binding to methylated oligonucleotide PubChem Bioassay (2013)[AID] 
Target
Name:
Methyl-CpG-binding domain protein 2
Synonyms:
MBD2 | MBD2_HUMAN | Methyl-CpG binding domain protein 2 | Methyl-CpG-binding domain protein 2 (MBD2)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
43278.74
Organism:
Homo sapiens (Human)
Description:
gi_21595776
Residue:
411
Sequence:
MRAHPGGGRCCPEQEEGESAAGGSGAGGDSAIEQGGQGSALAPSPVSGVRREGARGGGRGRGRWKQAGRGGGVCGRGRGRGRGRGRGRGRGRGRGRPPSGGSGLGGDGGGCGGGGSGGGGAPRREPVPFPSGSAGPGPRGPRATESGKRMDCPALPPGWKKEEVIRKSGLSAGKSDVYYFSPSGKKFRSKPQLARYLGNTVDLSSFDFRTGKMMPSKLQKNKQRLRNDPLNQNKGKPDLNTTLPIRQTASIFKQPVTKVTNHPSNKVKSDPQRMNEQPRQLFWEKRLQGLSASDVTEQIIKTMELPKGLQGVGPGSNDETLLSAVASALHTSSAPITGQVSAAVEKNPAVWLNTSQPLCKAFIVTDEDIRKQEERVQQVRKKLEEALMADILSRAADTEEMDIEMDSGDEA
  
Inhibitor
Name:
BDBM114648
Synonyms:
5-(1-butyl-1,2,3,4-tetrazol-5-yl)-1-(3-imidazol-1-ylpropyl)-5-methyl-pyrrolidin-2-one | 5-(1-butyl-5-tetrazolyl)-1-[3-(1-imidazolyl)propyl]-5-methyl-2-pyrrolidinone | 5-(1-butyltetrazol-5-yl)-1-(3-imidazol-1-ylpropyl)-5-methyl-2-pyrrolidone | 5-(1-butyltetrazol-5-yl)-1-(3-imidazol-1-ylpropyl)-5-methylpyrrolidin-2-one | MLS003552197 | SMR002203702 | cid_53300809
Type:
Small organic molecule
Emp. Form.:
C16H25N7O
Mol. Mass.:
331.416
SMILES:
CCCCn1nnnc1C1(C)CCC(=O)N1CCCn1ccnc1
Structure:
Search PDB for entries with ligand similarity: