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Target
Fibrinogen beta chain [164-491]
Ligand
BDBM50241461
Substrate
n/a
Meas. Tech.
Fluorescence polarization-based biochemical high throughput dose response assay to identify inhibitors that disrupt the binding of a cyclic peptide (Tn6) to the fibrin proteolytic product D-Dimer
IC50
9253±n/a nM
Citation
 PubChem, PC Fluorescence polarization-based biochemical high throughput dose response assay to identify inhibitors that disrupt the binding of a cyclic peptide (Tn6) to the fibrin proteolytic product D-Dimer and fragment E complex [DD(E )] PubChem Bioassay (2013)[AID] 
Target
Name:
Fibrinogen beta chain [164-491]
Synonyms:
Chain E, Fragment Double-D From Human Fibrin | FGB | FIBB_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
37647.12
Organism:
Homo sapiens (Human)
Description:
gi_28373962
Residue:
328
Sequence:
DNENVVNEYSSELEKHQLYIDETVNSNIPTNLRVLRSILENLRSKIQKLESDVSAQMEYCRTPCTVSCNIPVVSGKECEEIIRKGGETSEMYLIQPDSSVKPYRVYCDMNTENGGWTVIQNRQDGSVDFGRKWDPYKQGFGNVATNTDGKNYCGLPGEYWLGNDKISQLTRMGPTELLIEMEDWKGDKVKAHYGGFTVQNEANKYQISVNKYRGTAGNALMDGASQLMGENRTMTIHNGMFFSTYDRDNDGWLTSDPRKQCSKEDGGGWWYNRCHAANPNGRYYWGGQYTWDMAKHGTDDGVVWMNWKGSWYSMRKMSMKIRPFFPQQ
  
Inhibitor
Name:
BDBM50241461
Synonyms:
3,7-bis(dimethylamino)phenothiazin-5-ium chloride | Basic Blue 9 | CHEMBL405110 | Methylenblau | Methylene Blue anhydrous | Methylene blue | Methylene blue (10) | SAMPL5, CBC-G10 | azul de metileno | bleu de methylene | cid_6099 | methylthioninium chloride
Type:
Small organic molecule
Emp. Form.:
C16H18N3S
Mol. Mass.:
284.399
SMILES:
CN(C)c1ccc2nc3ccc(cc3sc2c1)=[N+](C)C |(17.73,-40.24,;19.06,-41.01,;19.06,-42.55,;20.39,-40.24,;20.4,-38.7,;21.73,-37.93,;23.06,-38.69,;24.39,-37.91,;25.73,-38.69,;27.06,-37.93,;28.39,-38.69,;28.39,-40.23,;27.06,-41,;25.73,-40.23,;24.39,-41.01,;23.06,-40.24,;21.73,-41.01,;29.73,-41,;29.73,-42.54,;31.06,-40.23,)|
Structure:
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