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Target
Protein artemis
Ligand
BDBM29623
Substrate
n/a
Meas. Tech.
Dose Response confirmation of small molecule inhibitors originally identified via uHTS of Artemis endonuclease activity via a fluorescence intensity assay
IC50
20000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of small molecule inhibitors originally identified via uHTS of Artemis endonuclease activity via a fluorescence intensity assay PubChem Bioassay (2013)[AID] 
Target
Name:
Protein artemis
Synonyms:
ARTEMIS | ASCID | DCLRE1C | DCR1C_HUMAN | SCIDA | SNM1C | protein artemis isoform a
Type:
Enzyme Catalytic Domain
Mol. Mass.:
78427.91
Organism:
Homo sapiens (Human)
Description:
gi_76496497
Residue:
692
Sequence:
MSSFEGQMAEYPTISIDRFDRENLRARAYFLSHCHKDHMKGLRAPTLKRRLECSLKVYLYCSPVTKELLLTSPKYRFWKKRIISIEIETPTQISLVDEASGEKEEIVVTLLPAGHCPGSVMFLFQGNNGTVLYTGDFRLAQGEAARMELLHSGGRVKDIQSVYLDTTFCDPRFYQIPSREECLSGVLELVRSWITRSPYHVVWLNCKAAYGYEYLFTNLSEELGVQVHVNKLDMFRNMPEILHHLTTDRNTQIHACRHPKAEEYFQWSKLPCGITSRNRIPLHIISIKPSTMWFGERSRKTNVIVRTGESSYRACFSFHSSYSEIKDFLSYLCPVNAYPNVIPVGTTMDKVVEILKPLCRSSQSTEPKYKPLGKLKRARTVHRDSEEEDDYLFDDPLPIPLRHKVPYPETFHPEVFSMTAVSEKQPEKLRQTPGCCRAECMQSSRFTNFVDCEESNSESEEEVGIPASLQGDLGSVLHLQKADGDVPQWEVFFKRNDEITDESLENFPSSTVAGGSQSPKLFSDSDGESTHISSQNSSQSTHITEQGSQGWDSQSDTVLLSSQERNSGDITSLDKADYRPTIKENIPASLMEQNVICPKDTYSDLKSRDKDVTIVPSTGEPTTLSSETHIPEEKSLLNLSTNADSQSSSDFEVPSTPEAELPKREHLQYLYEKLATGESIAVKKRKCSLLDT
  
Inhibitor
Name:
BDBM29623
Synonyms:
1-(2-furanylmethyl)-2-imino-5-oxo-N-(phenylmethyl)-3-dipyrido[1,2-d:3',4'-f]pyrimidinecarboxamide | 2-azanylidene-1-(furan-2-ylmethyl)-5-oxidanylidene-N-(phenylmethyl)dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide | MLS000077621 | N-benzyl-1-(2-furfuryl)-2-imino-5-keto-dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide | N-benzyl-1-(furan-2-ylmethyl)-2-imino-5-oxodipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxamide | SMR000034668 | cid_661575
Type:
Small organic molecule
Emp. Form.:
C24H19N5O3
Mol. Mass.:
425.4394
SMILES:
N=c1c(cc2c(nc3ccccn3c2=O)n1Cc1ccco1)C(=O)NCc1ccccc1
Structure:
Search PDB for entries with ligand similarity: