Reaction Details Report a problem with these data
Target
Protein artemis
Ligand
BDBM40678
Substrate
n/a
Meas. Tech.
Dose Response confirmation of small molecule inhibitors originally identified via uHTS of Artemis endonuclease activity via a fluorescence intensity assay
IC50
20000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of small molecule inhibitors originally identified via uHTS of Artemis endonuclease activity via a fluorescence intensity assay PubChem Bioassay (2013)[AID] 
Target
Name:
Protein artemis
Synonyms:
ARTEMIS | ASCID | DCLRE1C | DCR1C_HUMAN | SCIDA | SNM1C | protein artemis isoform a
Type:
Enzyme Catalytic Domain
Mol. Mass.:
78427.91
Organism:
Homo sapiens (Human)
Description:
gi_76496497
Residue:
692
Sequence:
MSSFEGQMAEYPTISIDRFDRENLRARAYFLSHCHKDHMKGLRAPTLKRRLECSLKVYLYCSPVTKELLLTSPKYRFWKKRIISIEIETPTQISLVDEASGEKEEIVVTLLPAGHCPGSVMFLFQGNNGTVLYTGDFRLAQGEAARMELLHSGGRVKDIQSVYLDTTFCDPRFYQIPSREECLSGVLELVRSWITRSPYHVVWLNCKAAYGYEYLFTNLSEELGVQVHVNKLDMFRNMPEILHHLTTDRNTQIHACRHPKAEEYFQWSKLPCGITSRNRIPLHIISIKPSTMWFGERSRKTNVIVRTGESSYRACFSFHSSYSEIKDFLSYLCPVNAYPNVIPVGTTMDKVVEILKPLCRSSQSTEPKYKPLGKLKRARTVHRDSEEEDDYLFDDPLPIPLRHKVPYPETFHPEVFSMTAVSEKQPEKLRQTPGCCRAECMQSSRFTNFVDCEESNSESEEEVGIPASLQGDLGSVLHLQKADGDVPQWEVFFKRNDEITDESLENFPSSTVAGGSQSPKLFSDSDGESTHISSQNSSQSTHITEQGSQGWDSQSDTVLLSSQERNSGDITSLDKADYRPTIKENIPASLMEQNVICPKDTYSDLKSRDKDVTIVPSTGEPTTLSSETHIPEEKSLLNLSTNADSQSSSDFEVPSTPEAELPKREHLQYLYEKLATGESIAVKKRKCSLLDT
  
Inhibitor
Name:
BDBM40678
Synonyms:
2-(4-chloranyl-3,5-dimethyl-phenoxy)-N-(4-pyrrolidin-1-ylphenyl)ethanamide | 2-(4-chloro-3,5-dimethyl-phenoxy)-N-(4-pyrrolidinophenyl)acetamide | 2-(4-chloro-3,5-dimethylphenoxy)-N-(4-pyrrolidin-1-ylphenyl)acetamide | 2-(4-chloro-3,5-dimethylphenoxy)-N-[4-(1-pyrrolidinyl)phenyl]acetamide | MLS000534350 | SMR000141782 | cid_1245566
Type:
Small organic molecule
Emp. Form.:
C20H23ClN2O2
Mol. Mass.:
358.862
SMILES:
Cc1cc(OCC(=O)Nc2ccc(cc2)N2CCCC2)cc(C)c1Cl
Structure:
Search PDB for entries with ligand similarity: