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Target
Protein artemis
Ligand
BDBM114692
Substrate
n/a
Meas. Tech.
Dose Response confirmation of small molecule inhibitors originally identified via uHTS of Artemis endonuclease activity via a fluorescence intensity assay
IC50
20000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of small molecule inhibitors originally identified via uHTS of Artemis endonuclease activity via a fluorescence intensity assay PubChem Bioassay (2013)[AID] 
Target
Name:
Protein artemis
Synonyms:
ARTEMIS | ASCID | DCLRE1C | DCR1C_HUMAN | SCIDA | SNM1C | protein artemis isoform a
Type:
Enzyme Catalytic Domain
Mol. Mass.:
78427.91
Organism:
Homo sapiens (Human)
Description:
gi_76496497
Residue:
692
Sequence:
MSSFEGQMAEYPTISIDRFDRENLRARAYFLSHCHKDHMKGLRAPTLKRRLECSLKVYLYCSPVTKELLLTSPKYRFWKKRIISIEIETPTQISLVDEASGEKEEIVVTLLPAGHCPGSVMFLFQGNNGTVLYTGDFRLAQGEAARMELLHSGGRVKDIQSVYLDTTFCDPRFYQIPSREECLSGVLELVRSWITRSPYHVVWLNCKAAYGYEYLFTNLSEELGVQVHVNKLDMFRNMPEILHHLTTDRNTQIHACRHPKAEEYFQWSKLPCGITSRNRIPLHIISIKPSTMWFGERSRKTNVIVRTGESSYRACFSFHSSYSEIKDFLSYLCPVNAYPNVIPVGTTMDKVVEILKPLCRSSQSTEPKYKPLGKLKRARTVHRDSEEEDDYLFDDPLPIPLRHKVPYPETFHPEVFSMTAVSEKQPEKLRQTPGCCRAECMQSSRFTNFVDCEESNSESEEEVGIPASLQGDLGSVLHLQKADGDVPQWEVFFKRNDEITDESLENFPSSTVAGGSQSPKLFSDSDGESTHISSQNSSQSTHITEQGSQGWDSQSDTVLLSSQERNSGDITSLDKADYRPTIKENIPASLMEQNVICPKDTYSDLKSRDKDVTIVPSTGEPTTLSSETHIPEEKSLLNLSTNADSQSSSDFEVPSTPEAELPKREHLQYLYEKLATGESIAVKKRKCSLLDT
  
Inhibitor
Name:
BDBM114692
Synonyms:
MLS000551244 | N-[2-[(2E)-2-(9-anthracenylmethylidene)hydrazinyl]-2-oxo-1-(4-oxo-3H-phthalazin-1-yl)ethyl]benzamide | N-[2-[(2E)-2-(anthracen-9-ylmethylidene)hydrazinyl]-2-oxidanylidene-1-(4-oxidanylidene-3H-phthalazin-1-yl)ethyl]benzamide | N-[2-[(2E)-2-(anthracen-9-ylmethylidene)hydrazinyl]-2-oxo-1-(4-oxo-3H-phthalazin-1-yl)ethyl]benzamide | N-[2-[(N'E)-N'-(9-anthrylmethylene)hydrazino]-2-keto-1-(4-keto-3H-phthalazin-1-yl)ethyl]benzamide | N-[[1-Anthracen-9-yl-meth-(E)-ylidene-hydrazinocarbonyl]-(4-hydroxy-phthalazin-1-yl)-methyl]-benzamid e | SMR000145170 | cid_9625759
Type:
Small organic molecule
Emp. Form.:
C32H23N5O3
Mol. Mass.:
525.5567
SMILES:
O=C(NN=Cc1c2ccccc2cc2ccccc12)C(NC(=O)c1ccccc1)c1n[nH]c(=O)c2ccccc12 |w:3.2|
Structure:
Search PDB for entries with ligand similarity: