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Target
Protein artemis
Ligand
BDBM83754
Substrate
n/a
Meas. Tech.
Dose Response confirmation of small molecule inhibitors originally identified via uHTS of Artemis endonuclease activity via a fluorescence intensity assay
IC50
2230±n/a nM
Citation
 PubChem, PC Dose Response confirmation of small molecule inhibitors originally identified via uHTS of Artemis endonuclease activity via a fluorescence intensity assay PubChem Bioassay (2013)[AID] 
Target
Name:
Protein artemis
Synonyms:
ARTEMIS | ASCID | DCLRE1C | DCR1C_HUMAN | SCIDA | SNM1C | protein artemis isoform a
Type:
Enzyme Catalytic Domain
Mol. Mass.:
78427.91
Organism:
Homo sapiens (Human)
Description:
gi_76496497
Residue:
692
Sequence:
MSSFEGQMAEYPTISIDRFDRENLRARAYFLSHCHKDHMKGLRAPTLKRRLECSLKVYLYCSPVTKELLLTSPKYRFWKKRIISIEIETPTQISLVDEASGEKEEIVVTLLPAGHCPGSVMFLFQGNNGTVLYTGDFRLAQGEAARMELLHSGGRVKDIQSVYLDTTFCDPRFYQIPSREECLSGVLELVRSWITRSPYHVVWLNCKAAYGYEYLFTNLSEELGVQVHVNKLDMFRNMPEILHHLTTDRNTQIHACRHPKAEEYFQWSKLPCGITSRNRIPLHIISIKPSTMWFGERSRKTNVIVRTGESSYRACFSFHSSYSEIKDFLSYLCPVNAYPNVIPVGTTMDKVVEILKPLCRSSQSTEPKYKPLGKLKRARTVHRDSEEEDDYLFDDPLPIPLRHKVPYPETFHPEVFSMTAVSEKQPEKLRQTPGCCRAECMQSSRFTNFVDCEESNSESEEEVGIPASLQGDLGSVLHLQKADGDVPQWEVFFKRNDEITDESLENFPSSTVAGGSQSPKLFSDSDGESTHISSQNSSQSTHITEQGSQGWDSQSDTVLLSSQERNSGDITSLDKADYRPTIKENIPASLMEQNVICPKDTYSDLKSRDKDVTIVPSTGEPTTLSSETHIPEEKSLLNLSTNADSQSSSDFEVPSTPEAELPKREHLQYLYEKLATGESIAVKKRKCSLLDT
  
Inhibitor
Name:
BDBM83754
Synonyms:
(6E)-6-[[2-[4-(3,5-dimethylpyrazol-1-yl)-6-phenylazanyl-1,3,5-triazin-2-yl]hydrazinyl]methylidene]-4-methoxy-cyclohexa-2,4-dien-1-one | (6E)-6-[[2-[4-anilino-6-(3,5-dimethylpyrazol-1-yl)-1,3,5-triazin-2-yl]hydrazinyl]methylidene]-4-methoxycyclohexa-2,4-dien-1-one | (6E)-6-[[N'-[4-anilino-6-(3,5-dimethylpyrazol-1-yl)-s-triazin-2-yl]hydrazino]methylene]-4-methoxy-cyclohexa-2,4-dien-1-one | (6E)-6-[[[4-anilino-6-(3,5-dimethyl-1-pyrazolyl)-1,3,5-triazin-2-yl]hydrazo]methylidene]-4-methoxy-1-cyclohexa-2,4-dienone | 2-hydroxy-5-methoxybenzaldehyde [4-anilino-6-(3,5-dimethyl-1H-pyrazol-1-yl)-1,3,5-triazin-2-yl]hydrazone | MLS000540768 | SMR000162192 | cid_6277393
Type:
Small organic molecule
Emp. Form.:
C22H22N8O2
Mol. Mass.:
430.4625
SMILES:
COc1ccc(O)c(CN=Nc2nc(Nc3ccccc3)nc(n2)-n2nc(C)cc2C)c1 |w:10.10|
Structure:
Search PDB for entries with ligand similarity: