Reaction Details Report a problem with these data
Target
Oxysterols receptor LXR-beta
Ligand
BDBM49904
Substrate
n/a
Meas. Tech.
Counterscreen for agonists of the daf-12 abnormal Dauer Formation: Luminescence-based cell-based dose response screening assay to identify agonists of the Liver-X-Receptor (LXR)
EC50
67459±n/a nM
Citation
 PubChem, PC Counterscreen for agonists of the daf-12 abnormal Dauer Formation: Luminescence-based cell-based dose response screening assay to identify agonists of the Liver-X-Receptor (LXR) PubChem Bioassay (2013)[AID] 
Target
Name:
Oxysterols receptor LXR-beta
Synonyms:
LXRB | Liver X receptor beta (NR1H2) | Liver X, LXR beta | NER | NR1H2 | NR1H2_HUMAN | Nuclear receptor NER | UNR | Ubiquitously-expressed nuclear receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50978.79
Organism:
Homo sapiens (Human)
Description:
P55055
Residue:
460
Sequence:
MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDWVIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
  
Inhibitor
Name:
BDBM49904
Synonyms:
1-(6-fluoranylpyridin-2-yl)-4-phenyl-pyrazol-3-amine | 1-(6-fluoro-2-pyridinyl)-4-phenyl-1H-pyrazol-3-amine | 1-(6-fluoro-2-pyridinyl)-4-phenyl-3-pyrazolamine | 1-(6-fluoropyridin-2-yl)-4-phenylpyrazol-3-amine | MLS000694607 | SMR000333273 | [1-(6-fluoro-2-pyridyl)-4-phenyl-pyrazol-3-yl]amine | cid_1478415
Type:
Small organic molecule
Emp. Form.:
C14H11FN4
Mol. Mass.:
254.2623
SMILES:
Nc1nn(cc1-c1ccccc1)-c1cccc(F)n1
Structure:
Search PDB for entries with ligand similarity: