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Target
Oxysterols receptor LXR-beta
Ligand
BDBM77798
Substrate
n/a
Meas. Tech.
Counterscreen for agonists of the daf-12 abnormal Dauer Formation: Luminescence-based cell-based dose response screening assay to identify agonists of the Liver-X-Receptor (LXR)
EC50
67527±n/a nM
Citation
 PubChem, PC Counterscreen for agonists of the daf-12 abnormal Dauer Formation: Luminescence-based cell-based dose response screening assay to identify agonists of the Liver-X-Receptor (LXR) PubChem Bioassay (2013)[AID] 
Target
Name:
Oxysterols receptor LXR-beta
Synonyms:
LXRB | Liver X receptor beta (NR1H2) | Liver X, LXR beta | NER | NR1H2 | NR1H2_HUMAN | Nuclear receptor NER | UNR | Ubiquitously-expressed nuclear receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50978.79
Organism:
Homo sapiens (Human)
Description:
P55055
Residue:
460
Sequence:
MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDWVIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
  
Inhibitor
Name:
BDBM77798
Synonyms:
MLS000769902 | N-[(5-bromanylthiophen-2-yl)methylideneamino]thiophene-2-carboxamide | N-[(5-bromo-2-thienyl)methyleneamino]thiophene-2-carboxamide | N-[(5-bromo-2-thiophenyl)methylideneamino]-2-thiophenecarboxamide | N-[(5-bromothiophen-2-yl)methylideneamino]thiophene-2-carboxamide | SMR000434730 | Thiophene-2-carboxylic acid [1-(5-bromo-thiophen-2-yl)-meth-(E)-ylidene]-hydrazide | cid_574108
Type:
Small organic molecule
Emp. Form.:
C10H7BrN2OS2
Mol. Mass.:
315.209
SMILES:
Brc1ccc(C=NNC(=O)c2cccs2)s1
Structure:
Search PDB for entries with ligand similarity: