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Target
PC4 and SFRS1-interacting protein
Ligand
BDBM115151
Substrate
n/a
Meas. Tech.
Counterscreen for inhibitors of LEDGF/p75-dependent integration: TR-FRET-based biochemical high throughput dose response counterscreen assay to identify activators of HIV-1 Integrase multimerization
IC50
1568±n/a nM
Citation
 PubChem, PC Counterscreen for inhibitors of LEDGF/p75-dependent integration: TR-FRET-based biochemical high throughput dose response counterscreen assay to identify activators of HIV-1 Integrase multimerization PubChem Bioassay (2014)[AID] 
Target
Name:
PC4 and SFRS1-interacting protein
Synonyms:
DFS70 | LEDGF | LEDGF/p75 | PSIP1 | PSIP1_HUMAN | PSIP2 | lens epithelium-derived growth factor p75
Type:
Enzyme Catalytic Domain
Mol. Mass.:
60120.68
Organism:
Homo sapiens (Human)
Description:
gi_6708281
Residue:
530
Sequence:
MTRDFKPGDLIFAKMKGYPHWPARVDEVPDGAVKPPTNKLPIFFFGTHETAFLGPKDIFPYSENKEKYGKPNKRKGFNEGLWEIDNNPKVKFSSQQAATKQSNASSDVEVEEKETSVSKEDTDHEEKASNEDVTKAVDITTPKAARRGRKRKAEKQVETEEAGVVTTATASVNLKVSPKRGRPAATEVKIPKPRGRPKMVKQPCPSESDIITEEDKSKKKGQEEKQPKKQPKKDEEGQKEEDKPRKEPDKKEGKKEVESKRKNLAKTGVTSTSDSEEEGDDQEGEKKRKGGRNFQTAHRRNMLKGQHEKEAADRKRKQEEQMETEQQNKDEGKKPEVKKVEKKRETSMDSRLQRIHAEIKNSLKIDNLDVNRCIEALDELASLQVTMQQAQKHTEMITTLKKIRRFKVSQVIMEKSTMLYNKFKNMFLVGEGDSVITQVLNKSLAEQRQHEEANKTKDQGKKGPNKKLEKEQTGSKTLNGGSDAQDGNQPQHNGESNEDSKDNHEASTKKKPSSEERETEISLKDSTLDN
  
Inhibitor
Name:
BDBM115151
Synonyms:
(4Z)-4-[(2,4-dihydroxyphenyl)hydrazinylidene]-3-oxo-1-naphthalenesulfonic acid | (4Z)-4-[(2,4-dihydroxyphenyl)hydrazinylidene]-3-oxonaphthalene-1-sulfonic acid | (4Z)-4-[(2,4-dihydroxyphenyl)hydrazono]-3-keto-naphthalene-1-sulfonic acid | (4Z)-4-[[2,4-bis(oxidanyl)phenyl]hydrazinylidene]-3-oxidanylidene-naphthalene-1-sulfonic acid | MLS002694782 | SMR001560701 | Sulfonaphtholazoresorcinol | cid_5483802
Type:
Small organic molecule
Emp. Form.:
C16H12N2O6S
Mol. Mass.:
360.341
SMILES:
Oc1ccc(N=Nc2c(O)cc(c3ccccc23)S(O)(=O)=O)c(O)c1 |w:6.6|
Structure:
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