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Target
PC4 and SFRS1-interacting protein
Ligand
BDBM61326
Substrate
n/a
Meas. Tech.
TR-FRET-based biochemical high throughput dose response assay to identify inhibitors of HIV-1 LEDGF/p75 DNA Integration
IC50
176.9±n/a nM
Citation
 PubChem, PC TR-FRET-based biochemical high throughput dose response assay to identify inhibitors of HIV-1 LEDGF/p75 DNA Integration PubChem Bioassay (2014)[AID] 
Target
Name:
PC4 and SFRS1-interacting protein
Synonyms:
DFS70 | LEDGF | LEDGF/p75 | PSIP1 | PSIP1_HUMAN | PSIP2 | lens epithelium-derived growth factor p75
Type:
Enzyme Catalytic Domain
Mol. Mass.:
60120.68
Organism:
Homo sapiens (Human)
Description:
gi_6708281
Residue:
530
Sequence:
MTRDFKPGDLIFAKMKGYPHWPARVDEVPDGAVKPPTNKLPIFFFGTHETAFLGPKDIFPYSENKEKYGKPNKRKGFNEGLWEIDNNPKVKFSSQQAATKQSNASSDVEVEEKETSVSKEDTDHEEKASNEDVTKAVDITTPKAARRGRKRKAEKQVETEEAGVVTTATASVNLKVSPKRGRPAATEVKIPKPRGRPKMVKQPCPSESDIITEEDKSKKKGQEEKQPKKQPKKDEEGQKEEDKPRKEPDKKEGKKEVESKRKNLAKTGVTSTSDSEEEGDDQEGEKKRKGGRNFQTAHRRNMLKGQHEKEAADRKRKQEEQMETEQQNKDEGKKPEVKKVEKKRETSMDSRLQRIHAEIKNSLKIDNLDVNRCIEALDELASLQVTMQQAQKHTEMITTLKKIRRFKVSQVIMEKSTMLYNKFKNMFLVGEGDSVITQVLNKSLAEQRQHEEANKTKDQGKKGPNKKLEKEQTGSKTLNGGSDAQDGNQPQHNGESNEDSKDNHEASTKKKPSSEERETEISLKDSTLDN
  
Inhibitor
Name:
BDBM61326
Synonyms:
1-N',2-N'-bis[(E)-(2-hydroxy-4-oxocyclohexa-2,5-dien-1-ylidene)methyl]ethanedihydrazide | MLS000974661 | N'~1~,N'~2~-bis(2,4-dihydroxybenzylidene)ethanedihydrazide | N1',N2'-bis[(E)-(2-hydroxy-4-keto-cyclohexa-2,5-dien-1-ylidene)methyl]oxalohydrazide | N1',N2'-bis[(E)-(2-hydroxy-4-oxo-1-cyclohexa-2,5-dienylidene)methyl]ethanedihydrazide | N1',N2'-bis[(E)-(2-oxidanyl-4-oxidanylidene-cyclohexa-2,5-dien-1-ylidene)methyl]ethanedihydrazide | SMR000496526 | cid_6508451
Type:
Small organic molecule
Emp. Form.:
C16H14N4O6
Mol. Mass.:
358.3056
SMILES:
Oc1ccc(C=NNC(=O)C(=O)NN=Cc2ccc(O)cc2O)c(O)c1 |w:6.6,13.12|
Structure:
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