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Target
Diacylglycerol O-acyltransferase 1 [89-488]
Ligand
BDBM120761
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
7.5±n/a
Temperature
277.15±n/a K
IC50
1180±n/a nM
Comments
extracted
Citation
 Forster, CJ; Kwak, Y; Nakajima, K; Wang, B Organic compounds US Patent  US8703761 Publication Date 4/22/2014 
Target
Name:
Diacylglycerol O-acyltransferase 1 [89-488]
Synonyms:
AGRP1 | DGAT | DGAT1 | DGAT1_HUMAN | acyl coA-diacylglycerol acyl transferase 1 (DGAT1)
Type:
Protein
Mol. Mass.:
46366.89
Organism:
Homo sapiens (Human)
Description:
O75907[89-488]
Residue:
400
Sequence:
LNWCVVMLILSNARLFLENLIKYGILVDPIQVVSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPAAVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHTVSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWMVPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREFYRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVSVPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVLNYEAPAAEA
  
Inhibitor
Name:
BDBM120761
Synonyms:
US8703761, 12-3
Type:
Small organic molecule
Emp. Form.:
C20H19F4N3O3S
Mol. Mass.:
457.442
SMILES:
CC(C)(NC(=O)C1(C)CC1)C(=O)Nc1nc(c(s1)C(=O)c1ccc(F)cc1)C(F)(F)F
Structure:
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