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Target
RNA-editing ligase 1, mitochondrial
Ligand
BDBM128133
Substrate
n/a
Meas. Tech.
Fluorescence-based biochemical high throughput dose response assay to identify inhibitors of Trypanosoma brucei RNA editing ligase 1 (TbREL1).
IC50
>96559±n/a nM
Citation
 PubChem, PC Fluorescence-based biochemical high throughput dose response assay to identify inhibitors of Trypanosoma brucei RNA editing ligase 1 (TbREL1). PubChem Bioassay (2014)[AID] 
Target
Name:
RNA-editing ligase 1, mitochondrial
Synonyms:
REL1 | RLGM1_TRYBB | Trypanosoma brucei RNA editing ligase 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
52299.36
Organism:
Trypanosoma brucei brucei
Description:
gi_342179211
Residue:
469
Sequence:
MQLQRLGAPLLKRLVGGCIRQSTAPIMPCVVVSGSGVFLTPVRTYMPLPNDQSDFSPYIEIDLPSESRIQSLHKSGLAAQEWVACEKVHGTNFGIYLINQGDHEVVRFAKRSGIMDPNENFFGYHILIDEFTAQIRILNDLLKQKYGLSRVGRLVLNGELFGAKYKHPLVPKSEKWCTLPNGKKFPIAGVQIQREPFPQYSPELHFFAFDIKYSVSGAEEDFVLLGYDEFVEFSSKVPNLLYARALVRGTLDECLAFDVENFMTPLPALLGLGNYPLEGNLAEGVVIRHVRRGDPAVEKHNVSTIIKLRCSSFMELKHPGKQKELKETFIDTVRSGALRRVRGNVTVISDSMLPQVEAAANDLLLNNVSDGRLSNVLSKIGREPLLSGEVSQVDVVLMLAKDALKDFLKEVDSLVLNTTLAFRKLLITNVYFESKRLVEQKWKELMQEEAAAQSEAIPPLSPAAPTKGE
  
Inhibitor
Name:
BDBM128133
Synonyms:
(4-benzoxy-3-methoxy-benzyl)-benzyl-[2-(dimethylamino)ethyl]amine;oxalic acid | MLS001181063 | N'-[(3-methoxy-4-phenylmethoxyphenyl)methyl]-N,N-dimethyl-N'-(phenylmethyl)ethane-1,2-diamine;oxalic acid | N'-benzyl-N'-[(3-methoxy-4-phenylmethoxyphenyl)methyl]-N,N-dimethylethane-1,2-diamine;oxalic acid | SMR000502260 | cid_23724277 | ethanedioic acid;N'-[(3-methoxy-4-phenylmethoxy-phenyl)methyl]-N,N-dimethyl-N'-(phenylmethyl)ethane-1,2-diamine
Type:
Small organic molecule
Emp. Form.:
C28H34N2O6
Mol. Mass.:
494.5794
SMILES:
OC(=O)C(O)=O.COc1cc(CN(CCN(C)C)Cc2ccccc2)ccc1OCc1ccccc1
Structure:
Search PDB for entries with ligand similarity: