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Target
RNA-editing ligase 1, mitochondrial
Ligand
BDBM128148
Substrate
n/a
Meas. Tech.
Fluorescence-based biochemical high throughput dose response assay to identify inhibitors of Trypanosoma brucei RNA editing ligase 1 (TbREL1).
IC50
>96559±n/a nM
Citation
 PubChem, PC Fluorescence-based biochemical high throughput dose response assay to identify inhibitors of Trypanosoma brucei RNA editing ligase 1 (TbREL1). PubChem Bioassay (2014)[AID] 
Target
Name:
RNA-editing ligase 1, mitochondrial
Synonyms:
REL1 | RLGM1_TRYBB | Trypanosoma brucei RNA editing ligase 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
52299.36
Organism:
Trypanosoma brucei brucei
Description:
gi_342179211
Residue:
469
Sequence:
MQLQRLGAPLLKRLVGGCIRQSTAPIMPCVVVSGSGVFLTPVRTYMPLPNDQSDFSPYIEIDLPSESRIQSLHKSGLAAQEWVACEKVHGTNFGIYLINQGDHEVVRFAKRSGIMDPNENFFGYHILIDEFTAQIRILNDLLKQKYGLSRVGRLVLNGELFGAKYKHPLVPKSEKWCTLPNGKKFPIAGVQIQREPFPQYSPELHFFAFDIKYSVSGAEEDFVLLGYDEFVEFSSKVPNLLYARALVRGTLDECLAFDVENFMTPLPALLGLGNYPLEGNLAEGVVIRHVRRGDPAVEKHNVSTIIKLRCSSFMELKHPGKQKELKETFIDTVRSGALRRVRGNVTVISDSMLPQVEAAANDLLLNNVSDGRLSNVLSKIGREPLLSGEVSQVDVVLMLAKDALKDFLKEVDSLVLNTTLAFRKLLITNVYFESKRLVEQKWKELMQEEAAAQSEAIPPLSPAAPTKGE
  
Inhibitor
Name:
BDBM128148
Synonyms:
2-(2-chlorophenoxy)ethyl-[2-(isopropylamino)-6-phenyl-thieno[3,2-d]pyrimidin-4-yl]amine | 4-N-[2-(2-chlorophenoxy)ethyl]-6-phenyl-2-N-propan-2-ylthieno[3,2-d]pyrimidine-2,4-diamine | MLS003123005 | N4-[2-(2-chloranylphenoxy)ethyl]-6-phenyl-N2-propan-2-yl-thieno[3,2-d]pyrimidine-2,4-diamine | N4-[2-(2-chlorophenoxy)ethyl]-6-phenyl-N2-propan-2-ylthieno[3,2-d]pyrimidine-2,4-diamine | SMR001277983 | cid_46942643
Type:
Small organic molecule
Emp. Form.:
C23H23ClN4OS
Mol. Mass.:
438.973
SMILES:
CC(C)Nc1nc(NCCOc2ccccc2Cl)c2sc(cc2n1)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: