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Target
RNA-editing ligase 1, mitochondrial
Ligand
BDBM128150
Substrate
n/a
Meas. Tech.
Fluorescence-based biochemical high throughput dose response assay to identify inhibitors of Trypanosoma brucei RNA editing ligase 1 (TbREL1).
IC50
>96559±n/a nM
Citation
 PubChem, PC Fluorescence-based biochemical high throughput dose response assay to identify inhibitors of Trypanosoma brucei RNA editing ligase 1 (TbREL1). PubChem Bioassay (2014)[AID] 
Target
Name:
RNA-editing ligase 1, mitochondrial
Synonyms:
REL1 | RLGM1_TRYBB | Trypanosoma brucei RNA editing ligase 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
52299.36
Organism:
Trypanosoma brucei brucei
Description:
gi_342179211
Residue:
469
Sequence:
MQLQRLGAPLLKRLVGGCIRQSTAPIMPCVVVSGSGVFLTPVRTYMPLPNDQSDFSPYIEIDLPSESRIQSLHKSGLAAQEWVACEKVHGTNFGIYLINQGDHEVVRFAKRSGIMDPNENFFGYHILIDEFTAQIRILNDLLKQKYGLSRVGRLVLNGELFGAKYKHPLVPKSEKWCTLPNGKKFPIAGVQIQREPFPQYSPELHFFAFDIKYSVSGAEEDFVLLGYDEFVEFSSKVPNLLYARALVRGTLDECLAFDVENFMTPLPALLGLGNYPLEGNLAEGVVIRHVRRGDPAVEKHNVSTIIKLRCSSFMELKHPGKQKELKETFIDTVRSGALRRVRGNVTVISDSMLPQVEAAANDLLLNNVSDGRLSNVLSKIGREPLLSGEVSQVDVVLMLAKDALKDFLKEVDSLVLNTTLAFRKLLITNVYFESKRLVEQKWKELMQEEAAAQSEAIPPLSPAAPTKGE
  
Inhibitor
Name:
BDBM128150
Synonyms:
6-[[4-[1-amino-2-[4-(trifluoromethyl)phenyl]ethyl]-1,3-thiazol-2-yl]amino]-N-butyl-N-methylpyridine-3-carboxamide | 6-[[4-[1-amino-2-[4-(trifluoromethyl)phenyl]ethyl]-2-thiazolyl]amino]-N-butyl-N-methyl-3-pyridinecarboxamide | 6-[[4-[1-amino-2-[4-(trifluoromethyl)phenyl]ethyl]thiazol-2-yl]amino]-N-butyl-N-methyl-nicotinamide | 6-[[4-[1-azanyl-2-[4-(trifluoromethyl)phenyl]ethyl]-1,3-thiazol-2-yl]amino]-N-butyl-N-methyl-pyridine-3-carboxamide | MLS003123668 | SMR001291949 | cid_49789865
Type:
Small organic molecule
Emp. Form.:
C23H26F3N5OS
Mol. Mass.:
477.546
SMILES:
CCCCN(C)C(=O)c1ccc(Nc2nc(cs2)C(N)Cc2ccc(cc2)C(F)(F)F)nc1
Structure:
Search PDB for entries with ligand similarity: