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Target
RNA-editing ligase 1, mitochondrial
Ligand
BDBM128168
Substrate
n/a
Meas. Tech.
Fluorescence-based biochemical high throughput dose response assay to identify inhibitors of Trypanosoma brucei RNA editing ligase 1 (TbREL1).
IC50
>96559±n/a nM
Citation
 PubChem, PC Fluorescence-based biochemical high throughput dose response assay to identify inhibitors of Trypanosoma brucei RNA editing ligase 1 (TbREL1). PubChem Bioassay (2014)[AID] 
Target
Name:
RNA-editing ligase 1, mitochondrial
Synonyms:
REL1 | RLGM1_TRYBB | Trypanosoma brucei RNA editing ligase 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
52299.36
Organism:
Trypanosoma brucei brucei
Description:
gi_342179211
Residue:
469
Sequence:
MQLQRLGAPLLKRLVGGCIRQSTAPIMPCVVVSGSGVFLTPVRTYMPLPNDQSDFSPYIEIDLPSESRIQSLHKSGLAAQEWVACEKVHGTNFGIYLINQGDHEVVRFAKRSGIMDPNENFFGYHILIDEFTAQIRILNDLLKQKYGLSRVGRLVLNGELFGAKYKHPLVPKSEKWCTLPNGKKFPIAGVQIQREPFPQYSPELHFFAFDIKYSVSGAEEDFVLLGYDEFVEFSSKVPNLLYARALVRGTLDECLAFDVENFMTPLPALLGLGNYPLEGNLAEGVVIRHVRRGDPAVEKHNVSTIIKLRCSSFMELKHPGKQKELKETFIDTVRSGALRRVRGNVTVISDSMLPQVEAAANDLLLNNVSDGRLSNVLSKIGREPLLSGEVSQVDVVLMLAKDALKDFLKEVDSLVLNTTLAFRKLLITNVYFESKRLVEQKWKELMQEEAAAQSEAIPPLSPAAPTKGE
  
Inhibitor
Name:
BDBM128168
Synonyms:
6-methyl-1-[3-(trifluoromethyl)benzyl]-4-[2-(trifluoromethyl)phenyl]-2-[(3,4,5-trimethoxybenzyl)amino]-4H-pyrimidine-5-carboxylic acid methyl ester | 6-methyl-4-[2-(trifluoromethyl)phenyl]-1-[[3-(trifluoromethyl)phenyl]methyl]-2-[(3,4,5-trimethoxyphenyl)methylamino]-4H-pyrimidine-5-carboxylic acid methyl ester | MLS003843157 | SMR002515870 | cid_53316260 | methyl 6-methyl-4-[2-(trifluoromethyl)phenyl]-1-[[3-(trifluoromethyl)phenyl]methyl]-2-[(3,4,5-trimethoxyphenyl)methylamino]-4H-pyrimidine-5-carboxylate
Type:
Small organic molecule
Emp. Form.:
C32H31F6N3O5
Mol. Mass.:
651.5961
SMILES:
COC(=O)C1=C(C)N(Cc2cccc(c2)C(F)(F)F)C(NCc2cc(OC)c(OC)c(OC)c2)=NC1c1ccccc1C(F)(F)F |c:4,35|
Structure:
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