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Target
RNA-editing ligase 1, mitochondrial
Ligand
BDBM128176
Substrate
n/a
Meas. Tech.
Fluorescence-based biochemical high throughput dose response assay to identify inhibitors of Trypanosoma brucei RNA editing ligase 1 (TbREL1).
IC50
>96559±n/a nM
Citation
 PubChem, PC Fluorescence-based biochemical high throughput dose response assay to identify inhibitors of Trypanosoma brucei RNA editing ligase 1 (TbREL1). PubChem Bioassay (2014)[AID] 
Target
Name:
RNA-editing ligase 1, mitochondrial
Synonyms:
REL1 | RLGM1_TRYBB | Trypanosoma brucei RNA editing ligase 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
52299.36
Organism:
Trypanosoma brucei brucei
Description:
gi_342179211
Residue:
469
Sequence:
MQLQRLGAPLLKRLVGGCIRQSTAPIMPCVVVSGSGVFLTPVRTYMPLPNDQSDFSPYIEIDLPSESRIQSLHKSGLAAQEWVACEKVHGTNFGIYLINQGDHEVVRFAKRSGIMDPNENFFGYHILIDEFTAQIRILNDLLKQKYGLSRVGRLVLNGELFGAKYKHPLVPKSEKWCTLPNGKKFPIAGVQIQREPFPQYSPELHFFAFDIKYSVSGAEEDFVLLGYDEFVEFSSKVPNLLYARALVRGTLDECLAFDVENFMTPLPALLGLGNYPLEGNLAEGVVIRHVRRGDPAVEKHNVSTIIKLRCSSFMELKHPGKQKELKETFIDTVRSGALRRVRGNVTVISDSMLPQVEAAANDLLLNNVSDGRLSNVLSKIGREPLLSGEVSQVDVVLMLAKDALKDFLKEVDSLVLNTTLAFRKLLITNVYFESKRLVEQKWKELMQEEAAAQSEAIPPLSPAAPTKGE
  
Inhibitor
Name:
BDBM128176
Synonyms:
2-(allylamino)-4-(3-fluorophenyl)-6-methyl-1-[3-(trifluoromethyl)benzyl]-4H-pyrimidine-5-carboxylic acid methyl ester | 4-(3-fluorophenyl)-6-methyl-2-(prop-2-enylamino)-1-[[3-(trifluoromethyl)phenyl]methyl]-4H-pyrimidine-5-carboxylic acid methyl ester | MLS003843182 | SMR002515895 | cid_53316037 | methyl 4-(3-fluorophenyl)-6-methyl-2-(prop-2-enylamino)-1-[[3-(trifluoromethyl)phenyl]methyl]-4H-pyrimidine-5-carboxylate
Type:
Small organic molecule
Emp. Form.:
C24H23F4N3O2
Mol. Mass.:
461.4519
SMILES:
COC(=O)C1=C(C)N(Cc2cccc(c2)C(F)(F)F)C(NCC=C)=NC1c1cccc(F)c1 |c:4,24|
Structure:
Search PDB for entries with ligand similarity: