Reaction Details Report a problem with these data
Target
Transthyretin
Ligand
BDBM128207
Substrate
n/a
Meas. Tech.
Counterscreen for activators of Transthyretin (TTR) transcription: Luminescence-based cell-based high throughput dose response assay to identify inhibitors of Transthyretin (TTR) transcription in HuH7
IC50
>18387±n/a nM
Citation
 PubChem, PC Counterscreen for activators of Transthyretin (TTR) transcription: Luminescence-based cell-based high throughput dose response assay to identify inhibitors of Transthyretin (TTR) transcription in HuH7 hepatoma cells PubChem Bioassay (2014)[AID] 
Target
Name:
Transthyretin
Synonyms:
ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR)
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Homo sapiens (Human)
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
  
Inhibitor
Name:
BDBM128207
Synonyms:
(Z)-2-(1,3-benzoxazol-2-yl)-3-(2-pyridinylamino)-2-propenal | (Z)-2-(1,3-benzoxazol-2-yl)-3-(2-pyridylamino)acrolein | (Z)-2-(1,3-benzoxazol-2-yl)-3-(pyridin-2-ylamino)prop-2-enal | 2-Benzooxazol-2-yl-3-(pyridin-2-ylamino)-propenal | MLS000525515 | SMR000115989 | cid_2249389
Type:
Small organic molecule
Emp. Form.:
C15H11N3O2
Mol. Mass.:
265.2667
SMILES:
O=C\C(=C/Nc1ccccn1)c1nc2ccccc2o1
Structure:
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