Reaction Details Report a problem with these data
Target
Transthyretin
Ligand
BDBM128210
Substrate
n/a
Meas. Tech.
Counterscreen for activators of Transthyretin (TTR) transcription: Luminescence-based cell-based high throughput dose response assay to identify inhibitors of Transthyretin (TTR) transcription in HuH7
IC50
>167158±n/a nM
Citation
 PubChem, PC Counterscreen for activators of Transthyretin (TTR) transcription: Luminescence-based cell-based high throughput dose response assay to identify inhibitors of Transthyretin (TTR) transcription in HuH7 hepatoma cells PubChem Bioassay (2014)[AID] 
Target
Name:
Transthyretin
Synonyms:
ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR)
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Homo sapiens (Human)
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
  
Inhibitor
Name:
BDBM128210
Synonyms:
1-[(1-methyl-1H-pyrazol-5-yl)carbonyl]indoline | 2,3-dihydroindol-1-yl-(2-methyl-3-pyrazolyl)methanone | 2,3-dihydroindol-1-yl-(2-methylpyrazol-3-yl)methanone | MLS000548512 | SMR000114733 | cid_725789 | indolin-1-yl-(2-methylpyrazol-3-yl)methanone
Type:
Small organic molecule
Emp. Form.:
C13H13N3O
Mol. Mass.:
227.2618
SMILES:
Cn1nccc1C(=O)N1CCc2ccccc12
Structure:
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