Target
Transthyretin
Ligand
BDBM128223
Substrate
n/a
Meas. Tech.
Counterscreen for activators of Transthyretin (TTR) transcription: Luminescence-based cell-based high throughput dose response assay to identify inhibitors of Transthyretin (TTR) transcription in HuH7
IC50
>167158±n/a nM
Citation
 PubChem, PC Counterscreen for activators of Transthyretin (TTR) transcription: Luminescence-based cell-based high throughput dose response assay to identify inhibitors of Transthyretin (TTR) transcription in HuH7 hepatoma cells PubChem Bioassay (2014)[AID] 
Target
Name:
Transthyretin
Synonyms:
ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR)
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Homo sapiens (Human)
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
  
Inhibitor
Name:
BDBM128223
Synonyms:
(4-bromanyl-2-methyl-pyrazol-3-yl)-(2,3-dihydroindol-1-yl)methanone | (4-bromo-2-methyl-3-pyrazolyl)-(2,3-dihydroindol-1-yl)methanone | (4-bromo-2-methyl-pyrazol-3-yl)-indolin-1-yl-methanone | (4-bromo-2-methylpyrazol-3-yl)-(2,3-dihydroindol-1-yl)methanone | 1-[(4-bromo-1-methyl-1H-pyrazol-5-yl)carbonyl]indoline | MLS000704145 | SMR000227173 | cid_903067
Type:
Small organic molecule
Emp. Form.:
C13H12BrN3O
Mol. Mass.:
306.158
SMILES:
Cn1ncc(Br)c1C(=O)N1CCc2ccccc12
Structure:
Search PDB for entries with ligand similarity: