Target
Transthyretin
Ligand
BDBM58653
Substrate
n/a
Meas. Tech.
Counterscreen for activators of Transthyretin (TTR) transcription: Luminescence-based cell-based high throughput dose response assay to identify inhibitors of Transthyretin (TTR) transcription in HuH7
IC50
>167158±n/a nM
Citation
 PubChem, PC Counterscreen for activators of Transthyretin (TTR) transcription: Luminescence-based cell-based high throughput dose response assay to identify inhibitors of Transthyretin (TTR) transcription in HuH7 hepatoma cells PubChem Bioassay (2014)[AID] 
Target
Name:
Transthyretin
Synonyms:
ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR)
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Homo sapiens (Human)
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
  
Inhibitor
Name:
BDBM58653
Synonyms:
MLS001074376 | N-[2-(3-phenyl-1-oxa-2,8-diazaspiro[4.5]dec-2-en-8-yl)-5-(propylcarbamoyl)phenyl]-2-furamide | N-[2-(3-phenyl-1-oxa-2,8-diazaspiro[4.5]dec-2-en-8-yl)-5-(propylcarbamoyl)phenyl]furan-2-carboxamide | N-[5-[oxo(propylamino)methyl]-2-(3-phenyl-1-oxa-2,8-diazaspiro[4.5]dec-2-en-8-yl)phenyl]-2-furancarboxamide | SMR000718491 | cid_24816792
Type:
Small organic molecule
Emp. Form.:
C28H30N4O4
Mol. Mass.:
486.5622
SMILES:
CCCNC(=O)c1ccc(N2CCC3(CC(=NO3)c3ccccc3)CC2)c(NC(=O)c2ccco2)c1 |c:15|
Structure:
Search PDB for entries with ligand similarity: