Reaction Details Report a problem with these data
Target
Transthyretin
Ligand
BDBM128241
Substrate
n/a
Meas. Tech.
Counterscreen for activators of Transthyretin (TTR) transcription: Luminescence-based cell-based high throughput dose response assay to identify inhibitors of Transthyretin (TTR) transcription in HuH7
IC50
>55162±n/a nM
Citation
 PubChem, PC Counterscreen for activators of Transthyretin (TTR) transcription: Luminescence-based cell-based high throughput dose response assay to identify inhibitors of Transthyretin (TTR) transcription in HuH7 hepatoma cells PubChem Bioassay (2014)[AID] 
Target
Name:
Transthyretin
Synonyms:
ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR)
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Homo sapiens (Human)
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
  
Inhibitor
Name:
BDBM128241
Synonyms:
(2,3-dimethylphenyl)-[3-(4-fluorophenyl)isoxazolo[5,4-d]pyrimidin-4-yl]-methyl-amine | MLS001143290 | N-(2,3-dimethylphenyl)-3-(4-fluorophenyl)-N-methyl-4-isoxazolo[5,4-d]pyrimidinamine | N-(2,3-dimethylphenyl)-3-(4-fluorophenyl)-N-methyl-[1,2]oxazolo[5,4-d]pyrimidin-4-amine | SMR000796266 | cid_24856208
Type:
Small organic molecule
Emp. Form.:
C20H17FN4O
Mol. Mass.:
348.3736
SMILES:
CN(c1cccc(C)c1C)c1ncnc2onc(-c3ccc(F)cc3)c12
Structure:
Search PDB for entries with ligand similarity: