Target
Transthyretin
Ligand
BDBM128242
Substrate
n/a
Meas. Tech.
Counterscreen for activators of Transthyretin (TTR) transcription: Luminescence-based cell-based high throughput dose response assay to identify inhibitors of Transthyretin (TTR) transcription in HuH7
IC50
66319±n/a nM
Citation
 PubChem, PC Counterscreen for activators of Transthyretin (TTR) transcription: Luminescence-based cell-based high throughput dose response assay to identify inhibitors of Transthyretin (TTR) transcription in HuH7 hepatoma cells PubChem Bioassay (2014)[AID] 
Target
Name:
Transthyretin
Synonyms:
ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR)
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Homo sapiens (Human)
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
  
Inhibitor
Name:
BDBM128242
Synonyms:
(2S,6R)-6-(2-fluorophenyl)-2-(4-methoxyphenyl)-1-(2-methylphenyl)sulfonyl-3,6-dihydro-2H-pyridine-5-carboxylic acid | (2S,6R)-6-(2-fluorophenyl)-2-(4-methoxyphenyl)-1-(o-tolylsulfonyl)-3,6-dihydro-2H-pyridine-5-carboxylic acid | MLS002174361 | SMR001261527 | cid_25102606
Type:
Small organic molecule
Emp. Form.:
C26H24FNO5S
Mol. Mass.:
481.536
SMILES:
COc1ccc(cc1)[C@@H]1CC=C([C@@H](N1S(=O)(=O)c1ccccc1C)c1ccccc1F)C(O)=O |c:11|
Structure:
Search PDB for entries with ligand similarity: