Reaction Details Report a problem with these data
Target
Transthyretin
Ligand
BDBM128245
Substrate
n/a
Meas. Tech.
Counterscreen for activators of Transthyretin (TTR) transcription: Luminescence-based cell-based high throughput dose response assay to identify inhibitors of Transthyretin (TTR) transcription in HuH7
IC50
114985±n/a nM
Citation
 PubChem, PC Counterscreen for activators of Transthyretin (TTR) transcription: Luminescence-based cell-based high throughput dose response assay to identify inhibitors of Transthyretin (TTR) transcription in HuH7 hepatoma cells PubChem Bioassay (2014)[AID] 
Target
Name:
Transthyretin
Synonyms:
ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR)
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Homo sapiens (Human)
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
  
Inhibitor
Name:
BDBM128245
Synonyms:
MLS003875108 | N-benzyl-N-methyl-carbamic acid [1-(2-methylbenzyl)triazol-4-yl]methyl ester | N-methyl-N-(phenylmethyl)carbamic acid [1-[(2-methylphenyl)methyl]-4-triazolyl]methyl ester | SMR002532133 | [1-[(2-methylphenyl)methyl]-1,2,3-triazol-4-yl]methyl N-methyl-N-(phenylmethyl)carbamate | [1-[(2-methylphenyl)methyl]triazol-4-yl]methyl N-benzyl-N-methylcarbamate | cid_60157353
Type:
Small organic molecule
Emp. Form.:
C20H22N4O2
Mol. Mass.:
350.4143
SMILES:
CN(Cc1ccccc1)C(=O)OCc1cn(Cc2ccccc2C)nn1
Structure:
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